Details

Autor(en) / Beteiligte

• van Dam, Koos P.J.
• Wieske, Luuk
• Stalman, Eileen W.
• Kummer, Laura Y.L.
• Roosen, Jesse
• van Kempen, Zoé L.E.
• Killestein, Joep
• Volkers, Adriaan G.
• Boekel, Laura
• Wolbink, Gerrit J.
• van der Kooi, Anneke J.
• Raaphorst, Joost
• Löwenberg, Mark
• Takkenberg, R. Bart
• D'Haens, Geert R.A.M.
• Spuls, Phyllis I.
• Bekkenk, Marcel W.
• Musters, Annelie H.
• Post, Nicoline F.
• Bosma, Angela L.
• Hilhorst, Marc L.
• Vegting, Yosta
• Bemelman, Frederike J.
• Voskuyl, Alexandre E.
• Broens, Bo
• Sanchez, Agner Parra
• van Els, Cécile A.C.M.
• de Wit, Jelle
• Rutgers, Abraham
• de Leeuw, Karina
• Horváth, Barbara
• Verschuuren, Jan J.G.M.
• Ruiter, Annabel M.
• van Ouwerkerk, Lotte
• van der Woude, Diane
• Allaart, Renée C.F.
• Teng, Y.K. Onno
• van Paassen, Pieter
• Busch, Matthias H.
• Jallah, Papay B.P.
• Brusse, Esther
• van Doorn, Pieter A.
• Baars, Adája E.
• Hijnen, Dirk Jan
• Schreurs, Corine R.G.
• van der Pol, W.Ludo
• Goedee, H. Stephan
• Steenhuis, Maurice
• Keijzer, Sofie
• Keijser, Jim B.D.
• Cristianawati, Olvi
• Rispens, Theo
• Brinke, Anja ten
• Verstegen, Niels J.M.
• Marieke van Ham, S.
• Tas, Sander W.
• Kuijpers, Taco W.
• Eftimov, Filip

Titel

Disease activity in patients with immune-mediated inflammatory diseases after SARS-CoV-2 vaccinations

Ist Teil von

• Journal of autoimmunity, 2023-02, Vol.135, p.102984-102984, Article 102984

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• For patients with immune-mediated inflammatory diseases (IMIDs), concerns exist about increased disease activity after vaccination. We aimed to assess changes in disease activity after SARS-CoV-2 vaccination in patients with IMIDs, and determine risk factors for increased disease activity. In this substudy of a prospective observational cohort study (Target-to-B!), we included patients with IMIDs who received a SARS-CoV-2 vaccine. Patients reported changes in disease activity on a five-point Likert scale every 60 days for up to twelve months after first vaccination. In case of self-reported increased activity, hospital records were screened whether the treating physician reported increased activity, and for potential intensification of immunosuppressive (ISP) treatment. Mixed models were used to study determinants for self-reported increased disease activity. In total, 2111 patients were included for analysis after primary immunization (mean age 49.7 years [SD 13.7], 1329/2111 (63.0%) female), from which 1266 patients for analysis after first additional vaccination. Increased disease activity at 60 days after start of primary immunization was reported by 223/2111 (10.6%). In 96/223 (43.0%) the increase was confirmed by the treating physician and in 36/223 (16.1%) ISP treatment was intensified. Increased disease activity at seven to 60 days after additional vaccination, was reported by 139/1266 (11.0%). Vaccinations were not temporally associated with self-reported increased disease activity. Conversely, increased disease activity before first vaccination, neuromuscular disease, and multiple sclerosis were associated. Altogether, self-reported increased disease activity after vaccination against SARS-CoV-2 was recorded in a minority of patients and was generally mild. Moreover, multivariate analyses suggest that disease related factors, but not vaccinations are the major determinants for self-reported increased disease activity. •Increased disease activity after SARS-CoV-2 vaccination was reported by a minority of patients.•When increased disease activity was reported, the increase in disease activity was generally mild.•No temporal relation was found between SARS-CoV-2 vaccination and self-reported increased disease activity.•Increased disease activity at follow-up was associated with increased activity before first vaccination and specific IMIDs.