Details

Autor(en) / Beteiligte

• Nicolas, Alexandre
• Sannier, Gérémy
• Dubé, Mathieu
• Nayrac, Manon
• Tauzin, Alexandra
• Painter, Mark M.
• Goel, Rishi R.
• Laporte, Mélanie
• Gendron-Lepage, Gabrielle
• Medjahed, Halima
• Williams, Justine C.
• Brassard, Nathalie
• Niessl, Julia
• Gokool, Laurie
• Morrisseau, Chantal
• Arlotto, Pascale
• Tremblay, Cécile
• Martel-Laferrière, Valérie
• Finzi, Andrés
• Greenplate, Allison R.
• Wherry, E. John
• Kaufmann, Daniel E.

Titel

Extended SARS-CoV-2 mRNA vaccine prime-boost intervals enhances B cell immunity with limited impact on T cells

Ist Teil von

• iScience, 2022-12

Ort / Verlag

The Authors

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Spacing the first two doses of SARS-CoV-2 mRNA vaccines beyond 3-4 weeks raised initial concerns about vaccine efficacy. While studies have since shown that long-interval regimens induce robust antibody responses, their impact on B and T cell immunity is poorly known. Here, we compare in SARS-CoV-2 naïve donors B and T cell responses to two mRNA vaccine doses administered 3-4 versus 16 weeks apart. After boost, the longer interval results in higher magnitude and a more mature phenotype of RBD-specific B cells. While the two geographically distinct cohorts present quantitative and qualitative differences in T cell responses at baseline and after priming, the second dose led to convergent features with overall similar magnitude, phenotype and function of CD4 + and CD8 + T cell responses at post-boost memory time points. Therefore, compared to standard regimens, a 16-week interval has a favorable impact on the B cell compartment but minimally affects T cell immunity.