Details

Autor(en) / Beteiligte

• Wan, Xueqi
• Tian, Jinfan
• Hao, Peng
• Zhou, Kuo
• Zhang, Jing
• Zhou, Yuquan
• Ge, Changjiang
• Song, Xiantao

Titel

cGAS-STING Pathway Performance in the Vulnerable Atherosclerotic Plaque

Ist Teil von

• Aging and disease, 2022-12, Vol.13 (6), p.1606-1614

Ort / Verlag

JKL International

Erscheinungsjahr

2022

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The important role of [Ca.sup.2+] in pathogenic store-operated calcium entry (SOCE) is well-established. Among the proteins involved in the calcium signaling pathway, Stromal interacting molecule 1 (STIM1) is a critical endoplasmic reticulum transmembrane protein. STIM1 is activated by the depletion of calcium stores and then binds to another calcium protein, Orai1, to form a channel through which the extracellular [Ca.sup.2+] can enter the cytoplasm to replenish the calcium store. Multiple studies have shown that increased STIM1 facilitates the aberrant proliferation and apoptosis of vascular smooth cells (VSMC) and macrophages which can promote the formation of rupture-prone plaque. Together with regulating the cytosolic [Ca.sup.2+] concentration, STIM1 also activates STING through altered intracellular [Ca.sup.2+] concentration, a critical pro-inflammatory molecule. The cGAS-STING pathway is linked with cellular proliferation and phenotypic conversion of VSMC and enhances the progression of atherosclerosis plaque. In summary, we conclude that STIM1/cGAS-STING is involved in the progression of AS and plaque vulnerability. Key words: atherosclerosis, plaque vulnerability, STIM1, STING, [Ca.sup.2+]