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Background
The pandemic 2009 swine flu is a highly infectious respiratory disorder caused by H1N1 influenza A viruses. A recent study reported that knockout of the prion protein gene (
PRNP
) induced susceptibility and lethality in influenza A virus-infected mice.
Objective
Thus, we examined the association between genetic variations of the
PRNP
gene and susceptibility to pandemic 2009 swine flu.
Results
We did not find an association between
PRNP
polymorphisms and susceptibility to pandemic 2009 swine flu.
Conclusions
To the best of our knowledge, this was the first evaluation of the association between
PRNP
polymorphisms and vulnerability to pandemic 2009 swine flu.