Details

Autor(en) / Beteiligte

• Kim, Yong-Chan
• Won, Sae-Young
• Jeong, Byung-Hoon

Titel

No association of prion protein gene (PRNP) polymorphisms with susceptibility to the pandemic 2009 swine flu

Ist Teil von

• Molecular & cellular toxicology, 2023-10, Vol.19 (4), p.799-803

Ort / Verlag

Singapore: Springer Nature Singapore

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Background The pandemic 2009 swine flu is a highly infectious respiratory disorder caused by H1N1 influenza A viruses. A recent study reported that knockout of the prion protein gene ( PRNP ) induced susceptibility and lethality in influenza A virus-infected mice. Objective Thus, we examined the association between genetic variations of the PRNP gene and susceptibility to pandemic 2009 swine flu. Results We did not find an association between PRNP polymorphisms and susceptibility to pandemic 2009 swine flu. Conclusions To the best of our knowledge, this was the first evaluation of the association between PRNP polymorphisms and vulnerability to pandemic 2009 swine flu.