Details

Autor(en) / Beteiligte

• Ricardo-Gonzalez, Roberto R.
• Kotas, Maya E.
• O’Leary, Claire E.
• Singh, Katelyn
• Damsky, William
• Liao, Chang
• Arouge, Elizabeth
• Tenvooren, Iliana
• Marquez, Diana M.
• Schroeder, Andrew W.
• Cohen, Jarish N.
• Fassett, Marlys S.
• Lee, Jinwoo
• Daniel, Scott G.
• Bittinger, Kyle
• Díaz, Roberto Efraín
• Fraser, James S.
• Ali, Niwa
• Ansel, K. Mark
• Spitzer, Matthew H.
• Liang, Hong-Erh
• Locksley, Richard M.

Titel

Innate type 2 immunity controls hair follicle commensalism by Demodex mites

Ist Teil von

• Immunity (Cambridge, Mass.), 2022-10, Vol.55 (10), p.1891-1908.e12

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Demodex mites are commensal parasites of hair follicles (HFs). Normally asymptomatic, inflammatory outgrowth of mites can accompany malnutrition, immune dysfunction, and aging, but mechanisms restricting Demodex outgrowth are not defined. Here, we show that control of mite HF colonization in mice required group 2 innate lymphoid cells (ILC2s), interleukin-13 (IL-13), and its receptor, IL-4Ra-IL-13Ra1. HF-associated ILC2s elaborated IL-13 that attenuated HFs and epithelial proliferation at anagen onset; in their absence, Demodex colonization led to increased epithelial proliferation and replacement of gene programs for repair by aberrant inflammation, leading to the loss of barrier function and HF exhaustion. Humans with rhinophymatous acne rosacea, an inflammatory condition associated with Demodex, had increased HF inflammation with decreased type 2 cytokines, consistent with the inverse relationship seen in mice. Our studies uncover a key role for skin ILC2s and IL-13, which comprise an immune checkpoint that sustains cutaneous integrity and restricts pathologic infestation by colonizing HF mites. [Display omitted] •Type 2 innate immunity is critical for normal commensalism with Demodex•In the absence of type 2 immunity, Demodex causes aberrant inflammation•IL-13 from ILC2s is coupled to the hair cycle and restrains stem cell proliferation•Decreased type 2 cytokine expression is observed in patients with rhinophyma Type 2 cytokines are well recognized for their role in mediating allergic pathologies in skin, but their role in normal skin physiology is unclear. Ricardo-Gonzalez et al. reveal that type 2 immunity restrains skin inflammation in response to injury that is necessary to control hair follicle commensalism by Demodex mites.