Details

Autor(en) / Beteiligte

• Borcherding, Nicholas
• Jia, Wentong
• Giwa, Rocky
• Field, Rachael L
• Moley, John R
• Kopecky, Benjamin J
• Chan, Mandy M
• Yang, Bin Q
• Sabio, Jessica M
• Walker, Emma C
• Osorio, Omar
• Bredemeyer, Andrea L
• Pietka, Terri
• Alexander-Brett, Jennifer
• Morley, Sharon Celeste
• Artyomov, Maxim N
• Abumrad, Nada A
• Schilling, Joel
• Lavine, Kory
• Crewe, Clair
• Brestoff, Jonathan R

Titel

Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood

Ist Teil von

• Cell metabolism, 2022-10, Vol.34 (10), p.1499-1513.e8

Ort / Verlag

United States

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Adipocytes transfer mitochondria to macrophages in white and brown adipose tissues to maintain metabolic homeostasis. In obesity, adipocyte-to-macrophage mitochondria transfer is impaired, and instead, adipocytes release mitochondria into the blood to induce a protective antioxidant response in the heart. We found that adipocyte-to-macrophage mitochondria transfer in white adipose tissue is inhibited in murine obesity elicited by a lard-based high-fat diet, but not a hydrogenated-coconut-oil-based high-fat diet, aging, or a corn-starch diet. The long-chain fatty acids enriched in lard suppress mitochondria capture by macrophages, diverting adipocyte-derived mitochondria into the blood for delivery to other organs, such as the heart. The depletion of macrophages rapidly increased the number of adipocyte-derived mitochondria in the blood. These findings suggest that dietary lipids regulate mitochondria uptake by macrophages locally in white adipose tissue to determine whether adipocyte-derived mitochondria are released into systemic circulation to support the metabolic adaptation of distant organs in response to nutrient stress.