Details

Autor(en) / Beteiligte

• PINTO, L. A.
• DE AZEREDO LEITÃO, L. A.
• MOCELLIN, M.
• ACOSTA, P.
• CABALLERO, M. T.
• LIBSTER, R.
• VARGAS, J. E.
• POLACK, F.
• COMARU, T.
• STEIN, R. T.
• DE SOUZA, A. P.

Titel

IL-8/IL-17 gene variations and the susceptibility to severe viral bronchiolitis

Ist Teil von

• Epidemiology and infection, 2017-03, Vol.145 (4), p.642-646

Ort / Verlag

Cambridge, UK: Cambridge University Press

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Clinical manifestations of acute bronchiolitis (AB) vary from minimal disease to severe respiratory failure. The response to respiratory viral infections is possibly influenced by genetic polymorphisms linked to the regulation of the inflammatory response. In the present study, we investigated whether interleukin-8 (IL-8) and interleukin-17 (IL-17) genetic variants are associated with the severity of AB. A group of Brazilian infants hospitalized with AB and a control group (infants with no or mild AB, without hospitalization) were genotyped for four IL-8/IL-17 variations. For replication, we studied an Argentinean population sample of infants with mild and severe AB. IL-8 polymorphism (rs 2227543) and IL-17 (rs2275913) variants showed significant associations with the severity of AB. The effect of the IL-8 variation could be replicated in the Argentinean sample. This finding suggests that IL-8 variations may influence the severity of AB in young infants. Further genetic association studies in low- or middle-income populations are necessary with the aim of expanding knowledge in this area.