Details

Autor(en) / Beteiligte

• Pizzorno, Andrés
• Padey, Blandine
• Dulière, Victoria
• Mouton, William
• Oliva, Justine
• Laurent, Emilie
• Milesi, Cedrine
• Lina, Bruno
• Traversier, Aurelien
• Julien, Thomas
• Trouillet-Assant, Sophie
• Rosa-Calatrava, Manuel
• Terrier, Olivier

Titel

Interactions Between Severe Acute Respiratory Syndrome Coronavirus 2 Replication and Major Respiratory Viruses in Human Nasal Epithelium

Ist Teil von

• The Journal of infectious diseases, 2022-12, Vol.226 (12), p.2095-2104

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

2022

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), along with extensive nonpharmacological interventions, have profoundly altered the epidemiology of major respiratory viruses. Some studies have described virus-virus interactions, particularly manifested by viral interference mechanisms at different scales. However, our knowledge of the interactions between SARS-CoV-2 and other respiratory viruses remains incomplete. Here, we studied the interactions between SARS-CoV-2 and several respiratory viruses (influenza, respiratory syncytial virus, human metapneumovirus, and human rhinovirus) in a reconstituted human epithelial airway model, exploring different scenarios affecting the sequence and timing of coinfections. We show that the virus type and sequence of infections are key factors in virus-virus interactions, the primary infection having a determinant role in the immune response to the secondary infection.