Details

Autor(en) / Beteiligte

• Guo, Shunhua
• Kapp, Meghan E
• Beltran, Diego M
• Cardona, Cesar Y
• Caster, Dawn J
• Reichel, Ronald R
• Fogo, Agnes B

Titel

Spectrum of Kidney Diseases in Patients With Hepatitis C Virus Infection: A 10-Year Study

Ist Teil von

• American journal of clinical pathology, 2021-09, Vol.156 (3), p.399-408

Ort / Verlag

Chicago: Oxford University Press

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Objectives: To study the pathologic spectrum of kidney diseases in patients with hepatitis C virus infection (HCV+). Methods: Native kidney biopsy specimens in HCV+ patients were reviewed. Results: A total of9,836 native kidney biopsy specimens were evaluated from January 2007 to December 2016, of which 273 (2.8%) were from HCV+ patients, and of these, 115 (42.1%) had diagnoses consistent with HCV-associated glomerulonephritis (GN). Non-HCV-associated kidney diseases comprised most diagnoses (158 cases, 57.9%) including non-immune complex-mediated kidney diseases (127 cases, 46.5%) and other immune complex-mediated glomerular diseases (31 cases, 11.4%). Forty-one (40.6%) patients had HCV-associated GN among 101 HCV+ patients from 2007 to 2011 vs 74 (43.0%) patients with HCVassociated GN among 172 HCV+ patients from 2012 to 2016. HCV-associated GN showed five morphologic patterns: focal proliferative (5.2%), diffuse mesangial proliferative (50.4%), diffuse membranoproliferative (28.7%), proliferative GN with crescentic lesions (7.8%), and membranous patterns (7.8%). Conclusions: We found a spectrum of pathologic changes in renal biopsy specimens of HCV+ patients, with most having diseases unrelated to HCV infection, HCV-associated GN showing five morphologic patterns, and availability of effective HCV antiviral therapy not yet resulting in major changes in the spectrum of kidney diseases in these patients. Key Words: Hepatitis C virus (HCV); Kidney disease; HCV-associated glomerulonephritis; Cryoglobulinemia