Details

Autor(en) / Beteiligte

• Quiroga, Borja
• Ortiz, Alberto
• Jaravaca Mantecón, Carlos Jesús
• Nava Pérez, Nathasha
• Sato, Yurika
• Lucena Valverde, Rafael
• Ortega Diaz, Mayra
• Calderón González, Carmen
• Pereira, Mónica
• González Parra, Emilio
• Sánchez Horrillo, Ana
• Sánchez González, Carmen
• Toapanta, Néstor
• Cigarrán Guldris, Secundino
• Sánchez Hernández, Rosa
• Pizarro Sánchez, Soledad
• Garcia-Fernández, Nuria
• Quiroz Morales, Manuel Augusto
• Escamilla-Cabrera, Beatriz
• Berdud Godoy, Isabel
• Gil-Casares Casanova, Beatriz
• Leyva, Alba
• Rojas, José
• Tocora, Daniel Gaitán
• Rodríguez, Mª Teresa Jaldo
• Suárez, Esther Rodriguez
• Santolaya, Alfredo José Sáenz
• Calero, Raquel Cerrajero
• Cobo, Patricia Arribas
• Ramos, Patricia Muñoz
• Gracia-Iguacel, Carolina
• Martin-Cleary, Catalina
• Ramos-Verde, Ana
• Giraldo, Yohana Gil
• Suárez, Pablo Ruano
• Perpén, Antonio Fernández
• Ramos, Andrés Fernández
• Villanueva, Laura Salanova
• Cortiñas, Alejandra
• Díez Arias, Pablo A
• Cárdenas, Alicia Cabrera
• de Santos, Antonio
• Núñez, Almudena
• Cuadrado, Guillermina Barril
• Repollet, Raquel
• Azancot, María Antonieta
• Ramos, Natalia
• Bestard, Oriol
• Cidraque, Ignacio
• Agraz, Irene
• Prat, Oreto
• Medina, Carlota
• Pardo, Emma
• Saiz, Alejandro
• Cabo, María Jesús Corton
• Alexandru, Simona
• Suarez, Laura García Puente
• Saico, Saul Pampa
• Tapia, Marisol Poma
• Osorio, Laura Rodríguez
• Zamora, Rocío
• Moreno, Paloma Leticia Martin
• Ortiz, Ana Sabalza
• Iñarrea, María Nieves Bastida
• García, Teresa
• Narváez, Carlos
• Orellana, Cristhian
• León, José Luis Pizarro
• García, Manuel Antonio Martínez
• Moya, Juan de Dios Ramiro
• Espinosa, Diana López
• Herrador, Alejandro Jiménez
• Zurita, Manuel Navarro
• Álvarez, Leonardo Díaz
• Martínez, Álvaro González
• Arroyo, Sandra Báez
• Fernández, Raquel Reina
• Useche, Gustavo
• de Miguel, Carmen Santamaría
• Palacios, Ángel
• Calve, Esther Orero
• Moya, José Lacueva
• Martínez, Lara Ruíz
• Arevalo, Marta Calvo
• Calvo, Jose Antonio Herrero
• Salgueira, Mercedes
• Aresté, Nuria
• Collantes, Rocío
• Hernández, Aurelio Pastor Rodríguez
• Rebollo, María Sagrario García
• de la Pisa, Ana María Urraca
• Monzon, Lidia Sendino
• Anachuri, Karina Ampuero
• Garcia, Esther Hernández
• Gomez, Victoria Oviedo
• Cavalotti, Ignacio Manzur
• López, Sol Otero
• González, Sara Outon
• Perich, Luis Guirado
• de la Rosa, Eva Cotilla

Titel

Anti-Spike antibodies 3 months after SARS-CoV-2 mRNA vaccine booster dose in patients on hemodialysis: the prospective SENCOVAC study

Ist Teil von

• Clinical kidney journal, 2022-10, Vol.15 (10), p.1856-1864

Ort / Verlag

Oxford University Press

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• ABSTRACT Background Patients on hemodialysis are at high-risk for complications derived from coronavirus disease 2019 (COVID-19). The present analysis evaluated the impact of a booster vaccine dose and breakthrough severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on humoral immunity 3 months after the booster dose. Methods This is a multicentric and prospective study assessing immunoglobulin G anti-Spike antibodies 6 and 9 months after initial SARS-CoV-2 vaccination in patients on hemodialysis that had also received a booster dose before the 6-month assessment (early booster) or between the 6- and 9-month assessments (late booster). The impact of breakthrough infections, type of vaccine, time from the booster and clinical variables were assessed. Results A total of 711 patients [67% male, median age (range) 67 (20–89) years] were included. Of these, 545 (77%) received an early booster and the rest a late booster. At 6 months, 64 (9%) patients had negative anti-Spike antibody titers (3% of early booster and 29% of late booster patients, P = .001). At 9 months, 91% of patients with 6-month negative response had seroconverted and there were no differences in residual prevalence of negative humoral response between early and late booster patients (0.9% vs 0.6%, P = .693). During follow-up, 35 patients (5%) developed breakthrough SARS-CoV-2 infection. Antibody titers at 9 months were independently associated with mRNA-1273 booster (P = .001), lower time from booster (P = .043) and past breakthrough SARS-CoV-2 infection (P < .001). Conclusions In hemodialysis patients, higher titers of anti-Spike antibodies at 9 months were associated with mRNA-1273 booster, lower time from booster and past breakthrough SARS-CoV-2 infection.