Details

Autor(en) / Beteiligte

• Schrijver, Irene T.
• Théroude, Charlotte
• Antonakos, Nikolaos
• Regina, Jean
• Le Roy, Didier
• Bart, Pierre‐Alexandre
• Chiche, Jean‐Daniel
• Perreau, Matthieu
• Pantaleo, Giuseppe
• Calandra, Thierry
• Roger, Thierry

Titel

COVID‐19 rapidly increases MDSCs and prolongs innate immune dysfunctions

Ist Teil von

• European journal of immunology, 2022-10, Vol.52 (10), p.1676-1679

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID‐19 induces a rapid, transient upregulation of myeloid‐derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. Blood MDSCs may represent biomarkers and targets for intervention strategies in COVID‐19 patients.