Details

Autor(en) / Beteiligte

• Kawamoto, Shinya
• Abe, Toshihiro
• Nagahori, Katsuhiro
• Yoshino, Atsunori
• Fujii, Akiko
• Ono, Yuko
• Ueda, Yoshihiko
• Takeda, Tetsuro

Titel

Anti-MDA5 Antibody-positive Dermatomyositis with Rapidly Progressive Interstitial Pneumonia Presenting with Nephrotic Syndrome during Treatment with Corticosteroids and Cyclosporine

Ist Teil von

• Internal Medicine, 2022/07/01, Vol.61(13), pp.2007-2012

Ort / Verlag

Tokyo: The Japanese Society of Internal Medicine

Erscheinungsjahr

2022

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• A 50-year-old Japanese woman with anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 antibody)-positive dermatomyositis presenting with rapidly progressive interstitial pneumonia was treated with corticosteroids and cyclosporine. She developed nephrotic syndrome during the treatment regimen with corticosteroids and cyclosporine. A kidney biopsy revealed a thrombotic microangiopathy (TMA) glomerular lesion. Anti-MDA5 antibody-positive dermatomyositis is prone to severe interstitial lung disease (ILD) and is often exacerbated and refractory to treatment. Renal symptoms might be due to TMA of the kidney, and this may be a sign that more intensive treatment is needed. Patients sometimes develop acute kidney injury, which may be due to the TMA.