Proteins, structure, function, and bioinformatics, 2021-12, Vol.89 (12), p.1711-1721
- Jumper, John
- Evans, Richard
- Pritzel, Alexander
- Green, Tim
- Figurnov, Michael
- Ronneberger, Olaf
- Tunyasuvunakool, Kathryn
- Bates, Russ
- Žídek, Augustin
- Potapenko, Anna
- Bridgland, Alex
- Meyer, Clemens
- Kohl, Simon A. A.
- Ballard, Andrew J.
- Cowie, Andrew
- Romera‐Paredes, Bernardino
- Nikolov, Stanislav
- Jain, Rishub
- Adler, Jonas
- Back, Trevor
- Petersen, Stig
- Reiman, David
- Clancy, Ellen
- Zielinski, Michal
- Steinegger, Martin
- Pacholska, Michalina
- Berghammer, Tamas
- Silver, David
- Vinyals, Oriol
- Senior, Andrew W.
- Kavukcuoglu, Koray
- Kohli, Pushmeet
- Hassabis, Demis
2021
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- Autor(en) / Beteiligte
- Jumper, John
- Evans, Richard
- Pritzel, Alexander
- Green, Tim
- Figurnov, Michael
- Ronneberger, Olaf
- Tunyasuvunakool, Kathryn
- Bates, Russ
- Žídek, Augustin
- Potapenko, Anna
- Bridgland, Alex
- Meyer, Clemens
- Kohl, Simon A. A.
- Ballard, Andrew J.
- Cowie, Andrew
- Romera‐Paredes, Bernardino
- Nikolov, Stanislav
- Jain, Rishub
- Adler, Jonas
- Back, Trevor
- Petersen, Stig
- Reiman, David
- Clancy, Ellen
- Zielinski, Michal
- Steinegger, Martin
- Pacholska, Michalina
- Berghammer, Tamas
- Silver, David
- Vinyals, Oriol
- Senior, Andrew W.
- Kavukcuoglu, Koray
- Kohli, Pushmeet
- Hassabis, Demis
- Titel
- Applying and improving AlphaFold at CASP14
- Ist Teil von
- Proteins, structure, function, and bioinformatics, 2021-12, Vol.89 (12), p.1711-1721
- Ort / Verlag
- Hoboken, USA: John Wiley & Sons, Inc
- Erscheinungsjahr
- 2021
- Quelle
- Wiley Online Library Journals Frontfile Complete
- Beschreibungen/Notizen
- We describe the operation and improvement of AlphaFold, the system that was entered by the team AlphaFold2 to the “human” category in the 14th Critical Assessment of Protein Structure Prediction (CASP14). The AlphaFold system entered in CASP14 is entirely different to the one entered in CASP13. It used a novel end‐to‐end deep neural network trained to produce protein structures from amino acid sequence, multiple sequence alignments, and homologous proteins. In the assessors' ranking by summed z scores (>2.0), AlphaFold scored 244.0 compared to 90.8 by the next best group. The predictions made by AlphaFold had a median domain GDT_TS of 92.4; this is the first time that this level of average accuracy has been achieved during CASP, especially on the more difficult Free Modeling targets, and represents a significant improvement in the state of the art in protein structure prediction. We reported how AlphaFold was run as a human team during CASP14 and improved such that it now achieves an equivalent level of performance without intervention, opening the door to highly accurate large‐scale structure prediction.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0887-3585eISSN: 1097-0134DOI: 10.1002/prot.26257Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9299164
- Format
- –
- Schlagworte
- AlphaFold, Amino Acid Sequence, Amino acids, Artificial neural networks, CASP, Computational Biology, Deep Learning, Homology, machine learning, Models, Molecular, Neural networks, Neural Networks, Computer, Predictions, Protein Conformation, Protein Folding, Protein structure, protein structure prediction, Proteins, Proteins - chemistry, Proteins - metabolism, Sequence Analysis, Protein, Software