Proceedings of the National Academy of Sciences - PNAS, 2022-05, Vol.119 (22), p.e2121406119-e2121406119
2022
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Details
- Autor(en) / Beteiligte
- Titel
- Orc6 is a component of the replication fork and enables efficient mismatch repair
- Ist Teil von
- Proceedings of the National Academy of Sciences - PNAS, 2022-05, Vol.119 (22), p.e2121406119-e2121406119
- Ort / Verlag
- United States: National Academy of Sciences
- Erscheinungsjahr
- 2022
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Significance Origin recognition complex (ORC) is required for the initiation of DNA replication. Unlike other ORC components, the role of human Orc6 in replication remains to be resolved. We identified an unexpected role for hOrc6, which is to promote S-phase progression after prereplication complex assembly and DNA damage response. Orc6 localizes at the replication fork, is an accessory factor of the mismatch repair complex, and plays a fundamental role in genome surveillance during S phase.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0027-8424eISSN: 1091-6490DOI: 10.1073/pnas.2121406119Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9295755
- Format
- –
- Schlagworte
- Assembly, Biological Sciences, Cell viability, Chromatin, Cytokinesis, Damage localization, Deoxyribonucleic acid, DNA, DNA biosynthesis, DNA damage, DNA Mismatch Repair, DNA-Binding Proteins - metabolism, Eukaryotes, Genomes, Humans, Mismatch repair, MutL Proteins - metabolism, Origin recognition complex, Origin Recognition Complex - genetics, Origin Recognition Complex - metabolism, Protein Binding, Repair, Replication, Replication initiation, S Phase, Yeast, Yeasts