Details

Autor(en) / Beteiligte

• Nguyen, Phuong Thi Lan
• Tran, Hung Thi Mai
• Tran, Hai Anh
• Pham, Thai Duy
• Luong, Tan Minh
• Nguyen, Thanh Ha
• Nguyen, Lien Thi Phuong
• Nguyen, Tho Thi Thi
• Hoang, Ha Thi An
• Nguyen, Chi
• Tran, Duong Nhu
• Dang, Anh Duc
• Suzuki, Masato
• Le, Thanh Viet
• Bañuls, Anne-Laure
• Choisy, Marc
• Van Doorn, Rogier H
• Tran, Huy Hoang

Titel

Carriage of Plasmid-Mediated Colistin Resistance-1-Positive Escherichia coli in Humans, Animals, and Environment on Farms in Vietnam

Ist Teil von

• The American journal of tropical medicine and hygiene, 2022-07, Vol.107 (1), p.65-71

Ort / Verlag

United States: Institute of Tropical Medicine

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Plasmid-Mediated Colistin Resistance 1 (mcr-1) was first reported in 2015 and is a great concern to human health. In this study, we investigated the prevalence of mcr-1 and mcr-1-positive Escherichia coli (MCRPEC) and the association in infection status among various reservoirs connected to livestock. The study was conducted in 70 poultry and swine farms in a commune in Ha Nam province, northern Vietnam. Samples were collected from farmers, food animals, domestic animals, and farm environments (flies and wastewater) for polymerase chain reaction (PCR) screening for mcr-1 gene and species identification of PCR positive isolates. Among 379 obtained mcr-1 positives isolates, Escherichia coli was the major identified, varying from 50% (2/4) in dog feces to 100% (31/31) in humans feces isolates. The prevalence of MCRPEC was 14.4% (20/139), 49.7% (96/193), 31.3% (25/80), 36.7% (40/109), 26.9% (18/67), and 3.9% (2/51) in humans, chickens, pigs, flies, wastewater, and dogs, respectively. The study identified association between MCRPEC infection status in humans and flies (OR = 3.4), between flies and chickens (OR = 5.3), and between flies and pigs (OR = 9.0). Farmers' age and farm livestock unit were also associated factors of MCRPEC infection status in humans (OR = 5.1 and 1.05, respectively). These findings bring new knowledge on antibiotic resistance in livestock setting and important suggestions on potential role of flies in the transmission of mcr-1 resistance gene.