Details

Autor(en) / Beteiligte

• Fung, Eva Lai-wah
• Mo, Chung-yin
• Fung, Sharon Tsui-Hang
• Chan, Anne Yin-yan
• Lau, Ka-yee
• Chan, Emily Kit-ying
• Chan, David Yuen-chung
• Zhu, Xian-lun
• Chan, Danny Tat-ming
• Poon, Wai-sang

Titel

Deep brain stimulation in a young child with GNAO1 mutation – Feasible and helpful

Ist Teil von

• Surgical neurology international, 2022-07, Vol.13, p.285, Article 285

Ort / Verlag

USA: Scientific Scholar

Erscheinungsjahr

2022

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Background: GNAO1 is an emerging disorder characterized with hypotonia, developmental delay, epilepsy, and movement disorder, which can be potentially life threatening during acute exacerbation. In the USA, deep brain stimulation (DBS) has been licensed for treating children with chronic, treatment-resistant primary dystonia, who are 7 years old or older. Case Description: A 4-year-old girl diagnosed to have GNAO1- related dyskinesia and severe global developmental delay. She had severe dyskinesia precipitated by intercurrent infection, requiring prolonged intensive care for heavy sedation and related complications. Her dyskinesia improved dramatically after DBS implantation. Technical difficulties and precautions of DBS in preschool children were discussed. Conclusion: DBS should be considered early in the treatment of drug-resistant movement disorders in young children with GNAO1 , especially after dyskinetic crisis, as they tend to recur. Presurgical counseling to parents and close monitoring of complications is also important in the process.