Details

Autor(en) / Beteiligte

• Lee, Jihoon W
• Su, Yapeng
• Baloni, Priyanka
• Chen, Daniel
• Pavlovitch-Bedzyk, Ana Jimena
• Yuan, Dan
• Duvvuri, Venkata R
• Ng, Rachel H
• Choi, Jongchan
• Xie, Jingyi
• Zhang, Rongyu
• Murray, Kim
• Kornilov, Sergey
• Smith, Brett
• Magis, Andrew T
• Hoon, Dave S B
• Hadlock, Jennifer J
• Goldman, Jason D
• Price, Nathan D
• Gottardo, Raphael
• Davis, Mark M
• Hood, Leroy
• Greenberg, Philip D
• Heath, James R

Titel

Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19

Ist Teil von

• Nature biotechnology, 2022-01, Vol.40 (1), p.110-120

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2022

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• A better understanding of the metabolic alterations in immune cells during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may elucidate the wide diversity of clinical symptoms experienced by individuals with coronavirus disease 2019 (COVID-19). Here, we report the metabolic changes associated with the peripheral immune response of 198 individuals with COVID-19 through an integrated analysis of plasma metabolite and protein levels as well as single-cell multiomics analyses from serial blood draws collected during the first week after clinical diagnosis. We document the emergence of rare but metabolically dominant T cell subpopulations and find that increasing disease severity correlates with a bifurcation of monocytes into two metabolically distinct subsets. This integrated analysis reveals a robust interplay between plasma metabolites and cell-type-specific metabolic reprogramming networks that is associated with disease severity and could predict survival.