Details

Autor(en) / Beteiligte

• Schierhorn, Kristina L
• Sanchez‐David, Raul Y
• Maillard, Pierre V

Titel

Mammalian antiviral RNAi is on the move

Ist Teil von

• The EMBO journal, 2022-06, Vol.41 (11), p.e111210-n/a

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2022

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• Recent work reported the existence of a mammalian cell‐autonomous antiviral defence based on RNA interference (RNAi), which relies on the accumulation of virus‐derived small interfering RNAs (vsiRNAs) to guide the degradation of complementary viral RNAs. In a new study, Zhang et al (2022) find that, in infected mice, vsiRNAs can enter the bloodstream via their incorporation into extracellular vesicles (EVs) and confer sequence‐specific antiviral activity to recipient cells, thus indicating that mammalian antiviral RNAi participates in both cell‐autonomous and non‐cell‐autonomous host defence. A recent study shows that virus‐derived small interfering RNAs (vsiRNAs) can enter the bloodstream in infected mice and confer sequence‐specific antiviral activity to recipient cells.