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Escherichia coli bacteraemia in adults: age-related differences in clinical and bacteriological characteristics, and outcome
Ist Teil von
Epidemiology and infection, 2014-12, Vol.142 (12), p.2672-2683
Ort / Verlag
Cambridge, UK: Cambridge University Press
Erscheinungsjahr
2014
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
To explore the specificities of Escherichia coli bacteraemia in the elderly, the demographic, clinical and bacteriological characteristics and in-hospital mortality rate of ‘young’ (18–64 years, n = 395), ‘old’ (65–79 years, n = 372) and ‘very old’ (⩾80 years, n = 284) adult patients of the multicentre COLIBAFI cohort study were compared. Clinical and bacteriological risk factors for death were jointly identified by logistic regression and multivariate analysis within each group. ‘Young’ and ‘old’ patients had more comorbidities than ‘very old’ patients (comorbidity score: 1·5 ± 1·3 and 1·6 ± 1·2 vs. 1·2 ± 1·2, respectively; P < 0·001), and were more frequently nosocomially infected (22·3% and 23·8% vs. 8·8%, respectively; P < 0·001). ‘Old’ patients had the poorest prognosis (death rate: 16·4% vs.10·4% for ‘young’ and 12·0% for ‘very old’ patients, respectively; P = 0·039). Risk factors for death were age group-specific, suggesting a host–pathogen relationship evolving with age.