The New England journal of medicine, 2020-09, Vol.383 (10), p.919-930
- Paganoni, Sabrina
- Macklin, Eric A
- Hendrix, Suzanne
- Berry, James D
- Elliott, Michael A
- Maiser, Samuel
- Karam, Chafic
- Caress, James B
- Owegi, Margaret A
- Quick, Adam
- Wymer, James
- Goutman, Stephen A
- Heitzman, Daragh
- Heiman-Patterson, Terry
- Jackson, Carlayne E
- Quinn, Colin
- Rothstein, Jeffrey D
- Kasarskis, Edward J
- Katz, Jonathan
- Jenkins, Liberty
- Ladha, Shafeeq
- Miller, Timothy M
- Scelsa, Stephen N
- Vu, Tuan H
- Fournier, Christina N
- Glass, Jonathan D
- Johnson, Kristin M
- Swenson, Andrea
- Goyal, Namita A
- Pattee, Gary L
- Andres, Patricia L
- Babu, Suma
- Chase, Marianne
- Dagostino, Derek
- Dickson, Samuel P
- Ellison, Noel
- Hall, Meghan
- Hendrix, Kent
- Kittle, Gale
- McGovern, Michelle
- Ostrow, Joseph
- Pothier, Lindsay
- Randall, Rebecca
- Shefner, Jeremy M
- Sherman, Alexander V
- Tustison, Eric
- Vigneswaran, Prasha
- Walker, Jason
- Yu, Hong
- Chan, James
- Wittes, Janet
- Cohen, Joshua
- Klee, Justin
- Leslie, Kent
- Tanzi, Rudolph E
- Gilbert, Walter
- Yeramian, Patrick D
- Schoenfeld, David
- Cudkowicz, Merit E
2020
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- Autor(en) / Beteiligte
- Paganoni, Sabrina
- Macklin, Eric A
- Hendrix, Suzanne
- Berry, James D
- Elliott, Michael A
- Maiser, Samuel
- Karam, Chafic
- Caress, James B
- Owegi, Margaret A
- Quick, Adam
- Wymer, James
- Goutman, Stephen A
- Heitzman, Daragh
- Heiman-Patterson, Terry
- Jackson, Carlayne E
- Quinn, Colin
- Rothstein, Jeffrey D
- Kasarskis, Edward J
- Katz, Jonathan
- Jenkins, Liberty
- Ladha, Shafeeq
- Miller, Timothy M
- Scelsa, Stephen N
- Vu, Tuan H
- Fournier, Christina N
- Glass, Jonathan D
- Johnson, Kristin M
- Swenson, Andrea
- Goyal, Namita A
- Pattee, Gary L
- Andres, Patricia L
- Babu, Suma
- Chase, Marianne
- Dagostino, Derek
- Dickson, Samuel P
- Ellison, Noel
- Hall, Meghan
- Hendrix, Kent
- Kittle, Gale
- McGovern, Michelle
- Ostrow, Joseph
- Pothier, Lindsay
- Randall, Rebecca
- Shefner, Jeremy M
- Sherman, Alexander V
- Tustison, Eric
- Vigneswaran, Prasha
- Walker, Jason
- Yu, Hong
- Chan, James
- Wittes, Janet
- Cohen, Joshua
- Klee, Justin
- Leslie, Kent
- Tanzi, Rudolph E
- Gilbert, Walter
- Yeramian, Patrick D
- Schoenfeld, David
- Cudkowicz, Merit E
- Titel
- Trial of Sodium Phenylbutyrate–Taurursodiol for Amyotrophic Lateral Sclerosis
- Ist Teil von
- The New England journal of medicine, 2020-09, Vol.383 (10), p.919-930
- Ort / Verlag
- United States: Massachusetts Medical Society
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Sodium phenylbutyrate combined with taurursodiol reduces neuronal endoplasmic reticulum stress and mitochondrial dysfunction in experimental models. In a randomized trial, the combination slowed the rate of progression of ALS but did not affect the slow vital capacity or isometric muscle strength.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-4793eISSN: 1533-4406DOI: 10.1056/NEJMoa1916945Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9134321
- Format
- –
- Schlagworte
- Age, Aged, Amyotrophic lateral sclerosis, Amyotrophic Lateral Sclerosis - drug therapy, Death, Design, Disease Progression, Double-Blind Method, Double-blind studies, Drug Combinations, Drug dosages, Female, Humans, Intention to Treat Analysis, Male, Middle Aged, Muscle contraction, Muscle strength, Neurofilaments, Ostomy, Pharmaceuticals, Phenylbutyrates - adverse effects, Phenylbutyrates - therapeutic use, Phenylbutyric acid, Severity of Illness Index, Sodium, Taurochenodeoxycholic Acid - administration & dosage, Taurochenodeoxycholic Acid - therapeutic use, Tracheostomy, Tracheotomy, Treatment Outcome