Nature biotechnology, 2022-05, Vol.40 (5), p.656-660
- Arnaud, Marion
- Chiffelle, Johanna
- Genolet, Raphael
- Navarro Rodrigo, Blanca
- Perez, Marta A. S.
- Huber, Florian
- Magnin, Morgane
- Nguyen-Ngoc, Tu
- Guillaume, Philippe
- Baumgaertner, Petra
- Chong, Chloe
- Stevenson, Brian J.
- Gfeller, David
- Irving, Melita
- Speiser, Daniel E.
- Schmidt, Julien
- Zoete, Vincent
- Kandalaft, Lana E.
- Bassani-Sternberg, Michal
- Bobisse, Sara
- Coukos, George
- Harari, Alexandre
2022
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- Autor(en) / Beteiligte
- Arnaud, Marion
- Chiffelle, Johanna
- Genolet, Raphael
- Navarro Rodrigo, Blanca
- Perez, Marta A. S.
- Huber, Florian
- Magnin, Morgane
- Nguyen-Ngoc, Tu
- Guillaume, Philippe
- Baumgaertner, Petra
- Chong, Chloe
- Stevenson, Brian J.
- Gfeller, David
- Irving, Melita
- Speiser, Daniel E.
- Schmidt, Julien
- Zoete, Vincent
- Kandalaft, Lana E.
- Bassani-Sternberg, Michal
- Bobisse, Sara
- Coukos, George
- Harari, Alexandre
- Titel
- Sensitive identification of neoantigens and cognate TCRs in human solid tumors
- Ist Teil von
- Nature biotechnology, 2022-05, Vol.40 (5), p.656-660
- Ort / Verlag
- New York: Nature Publishing Group US
- Erscheinungsjahr
- 2022
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-infiltrating lymphocytes. T cells transduced with tumor antigen-specific TCRs identified by NeoScreen mediate regression of established tumors in patient-derived xenograft mice. NeoScreen helps identify rare tumor antigens for personalized cancer vaccines and T cell therapies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1087-0156, 1546-1696eISSN: 1546-1696DOI: 10.1038/s41587-021-01072-6Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9110298
- Format
- –
- Schlagworte
- 631/250/1619/554/1775, 631/67/1059/2325, 692/308/575, Agriculture, Animals, Antigen (tumor-associated), Antigens, Antigens, Neoplasm - genetics, Bioinformatics, Biomedical and Life Sciences, Biomedical Engineering/Biotechnology, Biomedicine, Biotechnology, Brief Communication, Cancer vaccines, CD8-Positive T-Lymphocytes, Humans, Life Sciences, Lymphocytes, Lymphocytes T, Lymphocytes, Tumor-Infiltrating, Mice, Neoantigens, Neoplasms - genetics, Neoplasms - therapy, Receptors, Antigen, T-Cell - genetics, Solid tumors, T cell receptors, T-Lymphocytes, Tumor-infiltrating lymphocytes, Tumors, Xenografts, Xenotransplantation