Details

Autor(en) / Beteiligte

• Song, Meng-Meng
• Xiang, Hui-Hui
• Fei, Meng-Yu
• Lu, Da-Peng
• Jiang, Tong-Cui
• Yu, Yong-Qiang
• Liu, Rui
• Shen, Yu-Xian

Titel

Facile fabrication of water-dispersible nanocomposites based on hexa-peri-hexabenzocoronene and Fe3O4 for dual mode imaging (fluorescent/MR) and drug delivery

Ist Teil von

• RSC advances, 2018-01, Vol.8 (71), p.4554-4563

Ort / Verlag

Cambridge: Royal Society of Chemistry

Erscheinungsjahr

2018

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The facile fabrication of multifunctional nanocomposites (Fe 3 O 4 /HBC@F127) consisting of superparamagnetic Fe 3 O 4 nanoparticles and fluorescent organic hexa- peri -hexabenzocoronene (HBC) molecules incorporated in block copolymer diacylphospholipid-polyethyleneglycol F127 have been demonstrated for dual mode imaging (fluorescent/MR) and drug delivery. The obtained nanocomposites were water-dispersible, stable and biocompatible, as confirmed by dynamic light scattering (DLS) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Relativity measurements showed a T 2 relaxivity ( r 2 ) of 214.61 mM −1 s −1 , which may be used as T 2 -weighted MR imaging agents. In vitro imaging studies indicated that the nanocomposites had good MR and fluorescence imaging effects with low cytotoxicity. Besides, the developed nanocomposites could also be applied as drug delivery vehicles. Doxorubicin (DOX) loaded Fe 3 O 4 /HBC@F127 nanocomposites significantly inhibited the growth of human hepatoma cells (HepG2). These findings suggested that the facile synthesized multifunctional nanocomposites may be used as a platform for dual mode imaging (both MR and fluorescence) and drug delivery. Water-dispersible, stable and biocompatible dandelion-like Fe 3 O 4 /HBC@F127 nanocomposites were facilely developed for dual mode imaging (fluorescent/MR) and drug delivery.