Details

Autor(en) / Beteiligte

• Guida, José P.
• Cecatti, Jose G.
• Souza, Renato T.
• Pacagnella, Rodolfo C.
• Ribeiro-do-Valle, Carolina C.
• Luz, Adriana G.
• Lajos, Giuliane J.
• Surita, Fernanda G.
• Nobrega, Guilherme M.
• Griggio, Thayna B.
• Charles, Charles M.
• Miele, Maria J.
• Ferreira, Silvana B.
• Tedesco, Ricardo P.
• Fernandes, Karayna G.
• Martins-Costa, Sérgio H.A.
• Ramos, José G.L.
• Peret, Frederico J.A.
• Feitosa, Francisco E.
• Traina, Evelyn
• Cunha-Filho, Edson V.
• Vettorazzi, Janete
• Haddad, Samira M.
• Andreucci, Carla B.
• Correa-Junior, Mário D.
• Mayrink, Jussara
• Dias, Marcos A.B.
• Oliveira, Leandro G.
• Melo-Junior, Elias F.
• da Luz, Marília G.Q.
• Costa, Maria Laura

Titel

Preeclampsia among women with COVID-19 during pregnancy and its impact on maternal and perinatal outcomes: Results from a national multicenter study on COVID in Brazil, the REBRACO initiative

Ist Teil von

• Pregnancy hypertension, 2022-06, Vol.28, p.168-173

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •Women with COVID-19 were not more likely to have preeclampsia or HELLP syndrome.•Obesity and chronic hypertension increased the risk of preeclampsia in women with COVID-19.•COVID-19 did not change laboratorial manifestation of preeclampsia. To evaluate the prevalence of preeclampsia among cases of COVID-19 infection during pregnancy and the association between both conditions, in a multicenter cohort of Brazilian women with respiratory symptoms. Ancillary analysis of the Brazilian Network of COVID-19 in Obstetrics (REBRACO) study. We performed a nested case-control analysis selecting all women with COVID-19 and compared outcomes between women with and without PE. Maternal, gestational, and clinical characteristics and perinatal outcomes. Prevalence ratio (PR) and its 95%CI for each of the predictors and outcomes. A total of 203 women were included: 21 (10.3%) in PE group and 182 (89.7%) in non-PE group. Preeclampsia was not different among women with and without COVID-19 (10.3% vs 13.1%, p-value = 0.41), neither complication such as eclampsia and HELLP syndrome. Chronic hypertension (33.4%) (p < 0.01) and obesity (60.0%) (p = 0.03) were the most frequent comorbidities in PE group, and they were significantly more frequent in this group. Women with PE had more cesarean section (RR 5.54 [1.33 – 23.14]) and their neonates were more frequently admitted to neonatal intensive care unit (PR 2.46[1.06 – 5.69]), most likely due to preterm-birth-related complications. The prevalence of PE among women with COVID-19 infection during pregnancy was around 10%; women with COVID-19 and a history of chronic hypertension or obesity are more likely to have preeclampsia. Cesarean section is increased among women with PE and COVID-19, with increased rates of neonatal admission to intensive care units, mostly due to prematurity.