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Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Ist Teil von
RSC advances, 2020-08, Vol.1 (53), p.31991-31996
Ort / Verlag
England: Royal Society of Chemistry
Erscheinungsjahr
2020
Link zum Volltext
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Originating for the first time in Wuhan, China, the outbreak of SARS-CoV-2 has caused a serious global health issue. An effective treatment for SARS-CoV-2 is still unavailable. Therefore, in this study, we have tried to predict a list of potential inhibitors for SARS-CoV-2 main protease (Mpro) using a combination of molecular docking and fast pulling of ligand (FPL) simulations. The approaches were initially validated over a set of eleven available inhibitors. Both Autodock Vina and FPL calculations produced consistent results with the experiments with correlation coefficients of
R
Dock
= 0.72 ± 0.14 and
R
W
= −0.76 ± 0.10, respectively. The combined approaches were then utilized to predict possible inhibitors that were selected from a ZINC15 sub-database for SARS-CoV-2 Mpro. Twenty compounds were suggested to be able to bind well to SARS-CoV-2 Mpro. Among them, five top-leads are
periandrin V
,
penimocycline
,
cis-p-Coumaroylcorosolic acid
,
glycyrrhizin
, and
uralsaponin B
. The obtained results could probably lead to enhance the COVID-19 therapy.
A combination of Autodock Vina and FPL calculations suggested that
periandrin V
,
penimocycline
,
cis-p-Coumaroylcorosolic acid
,
glycyrrhizin
, and
uralsaponin B
are able to bind well to SARS-CoV-2 Mpro.