Details

Autor(en) / Beteiligte

• Martini, Veronica
• Edmans, Matthew
• Gubbins, Simon
• Jayaraman, Siddharth
• Paudyal, Basudev
• Morgan, Sophie
• McNee, Adam
• Morin, Théo
• Rijal, Pramila
• Gerner, Wilhelm
• Sewell, Andrew K
• Inoue, Ryo
• Bailey, Mick
• Connelley, Timothy
• Charleston, Bryan
• Townsend, Alain
• Beverley, Peter
• Tchilian, Elma

Titel

Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells

Ist Teil von

• Mucosal immunology, 2022-03, Vol.15 (3), p.428-442

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• For the first time we have defined naïve, central memory, effector memory and differentiated effector porcine CD8 T cells and analyzed their distribution in lymphoid and respiratory tissues after influenza infection or immunization, using peptide-MHC tetramers of three influenza nucleoprotein (NP) epitopes. The hierarchy of response to the three epitopes changes during the response in different tissues. Most NP-specific CD8 T cells in broncho-alveolar lavage (BAL) and lung are tissue resident memory cells (TRM) that express CD69 and downregulate CD45RA and CCR7. NP-specific cells isolated from BAL express genes characteristic of TRM, but gene expression differs at 7, 21 and 63 days post infection. In all tissues the frequency of NP-specific CD8 cells declines over 63 days almost to background levels but is best maintained in BAL. The kinetic of influenza specific memory CD8 T cell in this natural host species differs from that in small animal models.