Details

Autor(en) / Beteiligte

• Handler, Annie
• Graham, Thomas G.W.
• Cohn, Raphael
• Morantte, Ianessa
• Siliciano, Andrew F.
• Zeng, Jianzhi
• Li, Yulong
• Ruta, Vanessa

Titel

Distinct Dopamine Receptor Pathways Underlie the Temporal Sensitivity of Associative Learning

Ist Teil von

• Cell, 2019-06, Vol.178 (1), p.60-75.e19

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Animals rely on the relative timing of events in their environment to form and update predictive associations, but the molecular and circuit mechanisms for this temporal sensitivity remain incompletely understood. Here, we show that olfactory associations in Drosophila can be written and reversed on a trial-by-trial basis depending on the temporal relationship between an odor cue and dopaminergic reinforcement. Through the synchronous recording of neural activity and behavior, we show that reversals in learned odor attraction correlate with bidirectional neural plasticity in the mushroom body, the associative olfactory center of the fly. Two dopamine receptors, DopR1 and DopR2, contribute to this temporal sensitivity by coupling to distinct second messengers and directing either synaptic depression or potentiation. Our results reveal how dopamine-receptor signaling pathways can detect the order of events to instruct opposing forms of synaptic and behavioral plasticity, allowing animals to flexibly update their associations in a dynamic environment. [Display omitted] •The timing of odor and dopaminergic reinforcement instructs opposing associations•Bidirectional plasticity in the mushroom body correlates with these learned behaviors•Distinct DopR1 and DopR2 signaling cascades exhibit different temporal sensitivity•Behavioral and neural plasticity depend on the balance of DopR1 and DopR2 signaling Olfactory associations are formed and updated on a trial-by-trial basis depending on the timing of the odor presentation and reinforcement mediated by two dopamine receptor signaling pathways that play opposing roles in directing synaptic and behavioral plasticity in Drosophila.