Details

Autor(en) / Beteiligte

• Kogure, Mana
• Nakamura, Tomohiro
• Tsuchiya, Naho
• Hirata, Takumi
• Nochioka, Kotaro
• Narita, Akira
• Hatanaka, Rieko
• Itabashi, Fumi
• Kanno, Ikumi
• Obara, Taku
• Satoh, Michihiro
• Metoki, Hirohito
• Miyagawa, Ken
• Koshimizu, Hiroshi
• Nagayoshi, Sho
• Uruno, Akira
• Kikuya, Masahiro
• Suzuki, Kichiya
• Nakaya, Naoki
• Sugawara, Junichi
• Kuriyama, Shinichi
• Tsuji, Ichiro
• Kure, Shigeo
• Hozawa, Atsushi

Titel

Consideration of the reference value and number of measurements of the urinary sodium-to-potassium ratio based on the prevalence of untreated home hypertension: TMM Cohort Study

Ist Teil von

• Hypertension research, 2022-05, Vol.45 (5), p.866-875

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2022

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The sodium-to-potassium (Na/K) ratio is known to be associated with blood pressure (BP). However, no reference value has been established since the urinary Na/K (uNa/K) ratio is known to have diurnal and day-to-day variations. Therefore, we investigated the number of days required to yield a better association between the morning uNa/K ratio and home BP (HBP) and determined a morning uNa/K ratio value that can be used as a reference value in participants who are not taking antihypertensive medication. This was a cross-sectional study using data from the Tohoku Medical Megabank Project Cohort Study. A total of 3122 participants borrowed HBP and uNa/K ratio monitors for 10 consecutive days. We assessed the relationship between the morning uNa/K ratio from 1 day to 10 days and home hypertension (HBP ≥ 135/85 mmHg) using multiple logistic regression models. Although a 1-day measurement of the morning uNa/K ratio was positively associated with home hypertension, multiple measurements of the morning uNa/K ratio were strongly related to home hypertension. The average morning uNa/K ratio was relatively stable after 3 days (adjusted odds ratio of home hypertension per unit increase in the uNa/K ratio for more than 3 days: 1.19-1.23). In conclusion, there was no threshold for the uNa/K ratio, and the morning uNa/K ratio was linearly associated with home hypertension. The Na/K ratio 2.0 calculated from the Dietary Reference Intakes for Japanese might be a good indication. Regarding the stability of the association between the morning uNa/K ratio and BP, more than 3 days of measurements is desirable.