Details

Autor(en) / Beteiligte

• Rausch, Ivo
• Beitzke, Dietrich
• Li, Xiang
• Pfaff, Sahra
• Rasul, Sazan
• Haug, Alexander R.
• Mayerhoefer, Marius E.
• Hacker, Marcus
• Beyer, Thomas
• Cal-González, Jacobo

Titel

Accuracy of PET quantification in [68Ga]Ga-pentixafor PET/MR imaging of carotid plaques

Ist Teil von

• Journal of nuclear cardiology, 2022-04, Vol.29 (2), p.492-502

Ort / Verlag

Cham: Elsevier Inc

Erscheinungsjahr

2022

Quelle

SpringerLink

Beschreibungen/Notizen

• The aim of this study was to evaluate and correct for partial-volume-effects (PVE) on [68Ga]Ga-Pentixafor uptake in atherosclerotic plaques of the carotid arteries, and the impact of ignoring bone in MR-based attenuation correction (MR-AC). Twenty [68Ga]Ga-pentixafor PET/MR examinations including a high-resolution T2-TSE MR of the neck were included in this study. Carotid plaques located at the carotid bifurcation were delineated and the anatomical information was used for partial-volume-correction (PVC). Mean and max tissue-to-background ratios (TBR) of the [68Ga]Ga-Pentixafor uptake were compared for standard and PVC-PET images. A potential influence of ignoring bone in MR-AC was assessed in a subset of the data reconstructed after incorporating bone into MR-AC and a subsequent comparison of standardized-uptake values (SUV). In total, 34 atherosclerotic plaques were identified. Following PVC, mean and max TBR increased by 77 and 95%, respectively, when averaged across lesions. When accounting for bone in the MR-AC, SUV of plaque changed by 0.5%. Quantitative readings of [68Ga]Ga-pentixafor uptake in plaques are strongly affected by PVE, which can be reduced by PVC. Including bone information into the MR-AC yielded no clinically relevant effect on tracer quantification.