Details

Autor(en) / Beteiligte

• ROBERTS, M. C
• SUTCLIFFE, J
• COURVALIN, P
• JENSEN, L. B
• ROOD, J
• SEPPALA, H

Titel

Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants

Ist Teil von

• Antimicrobial agents and chemotherapy, 1999-12, Vol.43 (12), p.2823-2830

Ort / Verlag

Washington, DC: American Society for Microbiology

Erscheinungsjahr

1999

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Macrolides are composed of 14 (erythromycin and clarithromycin)-, 15 (azithromycin)-, or 16 (josamycin, spiramycin, and tylosin)-membered lactones to which are attached amino and/or neutral sugars via glycosidic bonds. Erythromycin was introduced in 1952 as the first macrolide antibiotic. Unfortunately, within a year, erythromycin-resistant (Em super(r)) staphylococci from the United States, Europe, and Japan were described. The binding site in the 50S ribosomal subunit for erythromycin overlaps the binding site of the newer macrolides, as well as the structurally unrelated lincosamides and streptogramin B antibiotics. The modification by methylase(s) reduces the binding of all three classes of antibiotics, which results in resistance against macrolides, lincosamides, and streptogramin B antibiotics (MLS sub(B)). In this review, we suggest a new nomenclature for naming MLS genes and propose to use the rules developed for identifying and naming new tetracycline resistance genes.