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Titel

SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

Ist Teil von

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2022

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

The recent emergence of B.1.1.529, the Omicron variant , has raised concerns of escape from protection by vaccines and therapeutic antibodies. A key test for potential countermeasures against B.1.1.529 is their activity in preclinical rodent models of respiratory tract disease. Here, using the collaborative network of the SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme of the National Institute of Allergy and Infectious Diseases (NIAID), we evaluated the ability of several B.1.1.529 isolates to cause infection and disease in immunocompetent and human ACE2 (hACE2)-expressing mice and hamsters. Despite modelling data indicating that B.1.1.529 spike can bind more avidly to mouse ACE2 (refs. ), we observed less infection by B.1.1.529 in 129, C57BL/6, BALB/c and K18-hACE2 transgenic mice than by previous SARS-CoV-2 variants, with limited weight loss and lower viral burden in the upper and lower respiratory tracts. In wild-type and hACE2 transgenic hamsters, lung infection, clinical disease and pathology with B.1.1.529 were also milder than with historical isolates or other SARS-CoV-2 variants of concern. Overall, experiments from the SAVE/NIAID network with several B.1.1.529 isolates demonstrate attenuated lung disease in rodents, which parallels preliminary human clinical data.

Sprache: Englisch
Identifikatoren: ISSN: 0028-0836
eISSN: 1476-4687
DOI: 10.1038/s41586-022-04441-6
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8942849

Format: –
Schlagworte: ACE2, Angiotensin-converting enzyme 2, Angiotensin-Converting Enzyme 2 - genetics, Angiotensin-Converting Enzyme 2 - metabolism, Animal models, Animals, Antibodies, Bronchopulmonary infection, Coronaviruses, COVID-19 - pathology, COVID-19 - virology, COVID-19 vaccines, Cricetinae, Disease Models, Animal, Female, Hamsters, Humans, Immunocompetence, Infections, Infectious diseases, Laboratories, Lung - pathology, Lung - virology, Lung diseases, Lungs, Male, Mesocricetus, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Pandemics, Pathogenesis, Proteins, Respiratory tract, Respiratory tract diseases, Rodents, SARS-CoV-2 - pathogenicity, Severe acute respiratory syndrome, Severe acute respiratory syndrome coronavirus 2, Transgenic animals, Transgenic mice, Vaccines, Viral diseases, Viral Load, Viruses, Weight loss

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