Details

Autor(en) / Beteiligte

• Damanti, Sarah
• Ramirez, Giuseppe Alvise
• Bozzolo, Enrica Paola
• Da Prat, Valentina
• Di Lucca, Giuseppe
• Di Terlizzi, Gaetano
• Marinosci, Alessandro
• Scotti, Raffaella
• Strada, Silvia
• Scarpellini, Paolo
• Castiglioni, Barbara
• Oltolini, Chiara
• Ripa, Marco
• Din, Chiara Tassan
• Centurioni, Clarissa Elisabeth
• Di Scala, Flavia
• Gobbi, Agnese
• Alba, Ada Carla
• Casiraghi, Giuseppina Maria
• Morgillo, Anna
• Tresoldi, Moreno

Titel

Frailty as a predictor of mortality in COVID-19 patients receiving CPAP for respiratory insufficiency

Ist Teil von

• Aging clinical and experimental research, 2022-04, Vol.34 (4), p.945-949

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Objective Exploring the association between frailty and mortality in a cohort of patients with COVID-19 respiratory insufficiency treated with continuous positive airway pressure. Methods Frailty was measured using a Frailty Index (FI) created by using the baseline assessment data on comorbidities and body mass index and baseline blood test results (including pH, lactate dehydrogenase, renal and liver function, inflammatory indexes and anemia). FI > 0.25 identified frail individuals. Results Among the 159 included individuals (81% men, median age of 68) frailty was detected in 69% of the patients (median FI score 0.3 ± 0.08). Frailty was associated to an increased mortality (adjusted HR 1.99, 95% CI 1.02–3.88, p  = 0.04). Conclusions Frailty is highly prevalent among patients with COVID-19, predicts poorer outcomes independently of age. A personalization of care balancing the risk and benefit of treatments (especially the invasive ones) in such complex patients is pivotal.