Details

Autor(en) / Beteiligte

• Pérez-Gómez, Marta
• Herrera-Ramírez, Piedad
• Bautista, Delia
• Saura-Llamas, Isabel
• García-López, José-Antonio

Titel

Synthesis of Benzofused O- and N‑Heterocycles through Cascade Carbopalladation/Cross-Alkylation of Alkynes Involving the C–C Cleavage of Cyclobutanols

Ist Teil von

• Organometallics, 2022-03, Vol.41 (5), p.649-658

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• We report a Pd-catalyzed route to heterocycles bearing a tetrasubstituted alkene fragment. Our approach merges the intramolecular carbopalladation of tethered alkynes with an alkylation step produced by the C–C cleavage of cyclobutanol derivatives. An alkenyl-Pd­(II) intermediate has been isolated and characterized by X-ray diffraction studies. Interestingly, the nature of the tethering alkynyl chain influences the E/Z stereochemistry of the alkenyl fragment in the functionalized heterocycles.