Clinical infectious diseases, 2022-03, Vol.74 (5), p.905-908
2022
Details
- Autor(en) / Beteiligte
- Titel
- Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA
- Ist Teil von
- Clinical infectious diseases, 2022-03, Vol.74 (5), p.905-908
- Ort / Verlag
- US: Oxford University Press
- Erscheinungsjahr
- 2022
- Link zum Volltext
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- Abstract We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1058-4838eISSN: 1537-6591DOI: 10.1093/cid/ciab511Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8906715
- Format
- –
- Schlagworte
- Anti-Bacterial Agents - pharmacology, Anti-Bacterial Agents - therapeutic use, Bacterial Proteins - genetics, beta-Lactamases - genetics, Brief Reports, Carbapenems - pharmacology, Carbapenems - therapeutic use, Cefiderocol, Cephalosporins, Enterobacter cloacae - genetics, Humans, Microbial Sensitivity Tests, Mutation, Siderophores - therapeutic use