Details

Autor(en) / Beteiligte

• de Lima Beltrão, Fabyan Esberard
• de Almeida Beltrão, Daniele Carvalhal
• Carvalhal, Giulia
• de Lima Beltrão, Fabricia Elizabeth
• de Souza Braga Filho, Jair
• de Brito Oliveira, Jocyel
• de Jesus, Joice Dos Santos
• Machado, Gabriel Jeferson Rodríguez
• Dos Santos Silva, Hatilla
• Teixeira, Helena Mariana Pitangueira
• Rodrigues, Juliana Lopes
• de Figueiredo, Camila Alexandrina Viana
• Dos Santos Costa, Ryan
• Hecht, Fabio
• Bianco, Antonio C
• da Conceição Rodrigues Gonçalves, Maria
• Ramos, Helton Estrela

Titel

Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19

Ist Teil von

• The journal of clinical endocrinology and metabolism, 2022-05, Vol.107 (6), p.e2488-e2501

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

2022

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The type 2 deiodinase and its Thr92Ala-DIO2 polymorphism have been linked to clinical outcomes in acute lung injury and pulmonary fibrosis. Our objectives were to evaluate were cumulative mortality during admission according to Thr92Ala-DIO2 polymorphism. Here we conducted an observational, longitudinal, and prospective cohort study to investigate a possible association between the Thr92Ala-DIO2 polymorphism and intrahospital mortality from COVID-19 in adult patients admitted between June and August 2020. Blood biochemistry, thyroid function tests, length of stay, comorbidities, complications, and severity scores were also studied according to Thr92Ala-DIO2 polymorphism. In total, 220 consecutive patients (median age 62; 48-74 years) were stratified into 3 subgroups: Thr/Thr (n = 79), Thr/Ala (n = 119), and Ala/Ala (n = 23). While the overall mortality was 17.3%, the lethality was lower in Ala/Thr patients (12.6%) than in Thr/Thr patients (21.7%) or Ala/Ala patients (23%). The heterozygous genotype (Thr/Ala) was associated with a 47% reduced risk of intrahospital mortality whereas univariate and multivariate logistic regression adjusted for multiple covariates revealed a reduction that ranged from 51% to 66%. The association of the Thr/Ala genotype with better clinical outcomes was confirmed in a metanalysis of 5 studies, including the present one. Here we provide evidence for a protective role played by Thr92Ala-DIO2 heterozygosity in patients with COVID-19. This protective effect follows an inheritance model known as overdominance, in which the phenotype of the heterozygote lies outside the phenotypical range of both homozygous.