Details

Autor(en) / Beteiligte

• STARČEVIĆ ČIZMAREVIĆ, N
• KAPOVIĆ, M
• RONČEVIĆ, D
• RISTIĆ, S

Titel

Could the CCR5-Δ32 Mutation be Protective in SARS-CoV-2 Infection?

Ist Teil von

• Physiological research, 2021-12, Vol.70 (Suppl 2), p.S249-S252

Ort / Verlag

Praha: Institute of Physiology

Erscheinungsjahr

2021

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Increasing evidence points to host genetics as a factor in COVID-19 prevalence and outcome. CCR5 is a receptor for proinflammatory chemokines that are involved in host responses, especially to viruses. The CCR5-Δ32 minor allele is an interesting variant, given the role of CCR5 in some viral infections, particularly HIV-1. Recent studies of the impact of CCR5-Δ32 on COVID-19 risk and severity have yielded contradictory results. This ecologic study shows that the CCR5-Δ32 allelic frequency in a European population was significantly negatively correlated with the number of COVID-19 cases (p=0.035) and deaths (p=0.006) during the second pandemic wave. These results suggest that CCR5-Δ32 may be protective against SARS-CoV-2 infection, as it is against HIV infection, and could be predictive of COVID-19 risk and severity. Further studies based on samples from populations of different genetic backgrounds are needed to validate these statistically obtained findings.