Details

Autor(en) / Beteiligte

• Awad, Mark M
• Liu, Shengwu
• Rybkin, Igor I
• Arbour, Kathryn C
• Dilly, Julien
• Zhu, Viola W
• Johnson, Melissa L
• Heist, Rebecca S
• Patil, Tejas
• Riely, Gregory J
• Jacobson, Joseph O
• Yang, Xiaoping
• Persky, Nicole S
• Root, David E
• Lowder, Kristen E
• Feng, Hanrong
• Zhang, Shannon S
• Haigis, Kevin M
• Hung, Yin P
• Sholl, Lynette M
• Wolpin, Brian M
• Wiese, Julie
• Christiansen, Jason
• Lee, Jessica
• Schrock, Alexa B
• Lim, Lee P
• Garg, Kavita
• Li, Mark
• Engstrom, Lars D
• Waters, Laura
• Lawson, J. David
• Olson, Peter
• Lito, Piro
• Ou, Sai-Hong I
• Christensen, James G
• Jänne, Pasi A
• Aguirre, Andrew J

Titel

Acquired Resistance to KRASG12C Inhibition in Cancer

Ist Teil von

• The New England journal of medicine, 2021-06, Vol.384 (25), p.2382-2393

Ort / Verlag

Boston: Massachusetts Medical Society

Erscheinungsjahr

2021

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• A study involving 38 patients who initially had a response to adagrasib or who had a long period of stable disease in response to the drug but then had progression yielded diverse mechanisms of acquired resistance in 45% of them. Unlike resistance to the tyrosine kinase inhibitors, the cancer cell uses many mechanisms to overcome the inhibition of KRAS.