Details

Autor(en) / Beteiligte

• Miklowitz, David J.
• Addington, Jean M.
• O'Brien, Mary P.
• Denenny, Danielle M.
• Weintraub, Marc J.
• Zinberg, Jamie L.
• Mathalon, Daniel H.
• Cornblatt, Barbara A.
• Friedman‐Yakoobian, Michelle S.
• Stone, William S.
• Cadenhead, Kristin S.
• Woods, Scott W.
• Sugar, Catherine A.
• Cannon, Tyrone D.
• Bearden, Carrie E.

Titel

Family‐focused therapy for individuals at high clinical risk for psychosis: A confirmatory efficacy trial

Ist Teil von

• Early intervention in psychiatry, 2022-06, Vol.16 (6), p.632-642

Ort / Verlag

Melbourne: Wiley Publishing Asia Pty Ltd

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• Aims Young people with attenuated psychotic symptoms (APS), brief intermittent psychosis, and/or genetic risk and functional deterioration are at high risk for developing psychotic disorders. In a prior trial, family‐focused therapy for clinical high risk youth (FFT‐CHR) was more effective than brief psychoeducation in reducing APS severity over 6 months. This 7‐site trial will compare the efficacy of FFT‐CHR to a psychoeducational and supportive intervention (enhanced care) on APS and social functioning in CHR individuals over 18 months. Methods Participants (N = 220, ages 13–25 years) with a CHR syndrome will be randomly assigned to FFT‐CHR (18 1‐h sessions of family psychoeducation and communication/problem‐solving skills training) or enhanced care (3 1‐h family psychoeducational sessions followed by 5 individual support sessions), both given over 6 months. Participants will rate their weekly progress during treatment using a mobile‐enhanced online platform. Family communication will be assessed in a laboratory interactional task at baseline and post‐treatment. Independent evaluators will assess APS (primary outcome) and psychosocial functioning (secondary outcome) every 6 months over 18 months. Results We hypothesize that, compared to enhanced care, FFT‐CHR will be associated with greater improvements in APS and psychosocial functioning over 18 months. Secondarily, improvements in family communication over 6 months will mediate the relationship between treatment condition and primary and secondary outcomes over 18 months. The effects of FFT‐CHR are predicted to be greater in individuals with higher baseline risk for psychosis conversion. Conclusions Results of the trial will inform treatment guidelines for individuals at high risk for psychosis.