Journal of the American Society of Nephrology, 2021-11, Vol.32 (11), p.2697-2713
2021
Details
- Autor(en) / Beteiligte
- Titel
- Podocyte Aging: Why and How Getting Old Matters
- Ist Teil von
- Journal of the American Society of Nephrology, 2021-11, Vol.32 (11), p.2697-2713
- Ort / Verlag
- United States: American Society of Nephrology
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The effects of healthy aging on the kidney, and how these effects intersect with superimposed diseases, are highly relevant in the context of the population's increasing longevity. Age-associated changes to podocytes, which are terminally differentiated glomerular epithelial cells, adversely affect kidney health. This review discusses the molecular and cellular mechanisms underlying podocyte aging, how these mechanisms might be augmented by disease in the aged kidney, and approaches to mitigate progressive damage to podocytes. Furthermore, we address how biologic pathways such as those associated with cellular growth confound aging in humans and rodents.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1046-6673eISSN: 1533-3450DOI: 10.1681/asn.2021050614Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8806106
- Format
- –
- Schlagworte
- Adult, Aged, Aging - physiology, Animals, Autophagy, Caloric Restriction, Cell Cycle, Cell Shape, Cells, Cultured, Cellular Senescence, DNA Damage, Female, Gene Expression, Humans, Inflammasomes, Kidney Glomerulus - cytology, Kidney Glomerulus - growth & development, Male, Mice, Middle Aged, Mitochondria - metabolism, Models, Animal, Oligopeptides - pharmacology, Oxidative Stress, Podocytes - cytology, Podocytes - metabolism, Rats, Regulated Cell Death, Sirtuins - metabolism, Species Specificity, Up Front Matters, Young Adult