Cellular and molecular life sciences : CMLS, 2022-02, Vol.79 (2), p.102-102, Article 102
2022
Details
- Autor(en) / Beteiligte
- Titel
- A20 undermines alternative NF-κB activity and expression of anti-apoptotic genes in Helicobacter pylori infection
- Ist Teil von
- Cellular and molecular life sciences : CMLS, 2022-02, Vol.79 (2), p.102-102, Article 102
- Ort / Verlag
- Cham: Springer International Publishing
- Erscheinungsjahr
- 2022
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A hallmark of infection by the pathogen Helicobacter pylori , which colonizes the human gastric epithelium, is the simultaneous activation of the classical and alternative nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathways, underlying inflammation and cell survival. Here, we report that the classical NF-κB target gene product A20 contributes to the negative regulation of alternative NF-κB signaling in gastric epithelial cells infected by H. pylori . Mechanistically, the de novo synthesized A20 protein interacts with tumor necrosis factor receptor-associated factor-interacting protein with forkhead-associated domain (TIFA) and thereby interferes with the association of TIFA with the NIK regulatory complex. We also show that alternative NF-κB activity contributes to the up-regulation of anti-apoptotic genes, such as baculoviral IAP repeat containing 2 ( BIRC2) , BIRC3 and B-cell lymphoma 2-related protein A1 ( BCL2A1) in gastric epithelial cells. Furthermore, the observed over-expression of RelB in human gastric biopsies with type B gastritis and RelB-dependent suppression of apoptotic cell death emphasize an important role of the alternative NF-κB pathway in H. pylori infection.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1420-682XeISSN: 1420-9071DOI: 10.1007/s00018-022-04139-yTitel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8799570
- Format
- –
- Schlagworte
- A20 protein, Apoptosis, Apoptosis Regulatory Proteins - genetics, Apoptosis Regulatory Proteins - metabolism, B-cell lymphoma, Baculoviral IAP Repeat-Containing 3 Protein - genetics, Baculoviral IAP Repeat-Containing 3 Protein - metabolism, Biochemistry, Biomedical and Life Sciences, Biomedicine, Biopsy, Cell Biology, Cell death, Cell Line, Tumor, Cell survival, Epithelial cells, Epithelium, Forkhead protein, Gastric Mucosa - metabolism, Gastric Mucosa - microbiology, Gastritis, Gastritis - genetics, Gastritis - metabolism, Gastritis - microbiology, Gene Expression, Gene Knockout Techniques, Gene regulation, Genes, Helicobacter Infections - genetics, Helicobacter Infections - metabolism, Helicobacter Infections - microbiology, Helicobacter pylori, Helicobacter pylori - physiology, Host-Pathogen Interactions, Humans, Infections, Life Sciences, Lymphocytes B, Lymphoma, Minor Histocompatibility Antigens - genetics, Minor Histocompatibility Antigens - metabolism, NF-kappa B - genetics, NF-kappa B - metabolism, NF-κB protein, Original, Original Article, Overexpression, Proteins, Proto-Oncogene Proteins c-bcl-2 - genetics, Proto-Oncogene Proteins c-bcl-2 - metabolism, RelB protein, Signal Transduction - genetics, Transcription Factor RelA - genetics, Transcription Factor RelA - metabolism, Transcription Factor RelB - genetics, Transcription Factor RelB - metabolism, Tumor Necrosis Factor alpha-Induced Protein 3 - genetics, Tumor Necrosis Factor alpha-Induced Protein 3 - metabolism