Details

Autor(en) / Beteiligte

• Nakase, Hiroshi
• Hayashi, Yuki
• Hirayama, Daisuke
• Matsumoto, Takayuki
• Matsuura, Minoru
• Iijima, Hideki
• Matsuoka, Katsuyoshi
• Ohmiya, Naoki
• Ishihara, Shunji
• Hirai, Fumihito
• Abukawa, Daiki
• Hisamatsu, Tadakazu

Titel

Interim analysis of a multicenter registry study of COVID-19 patients with inflammatory bowel disease in Japan (J-COSMOS)

Ist Teil von

• Journal of gastroenterology, 2022-03, Vol.57 (3), p.174-184

Ort / Verlag

Singapore: Springer Singapore

Erscheinungsjahr

2022

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background The spread of coronavirus disease 2019 (COVID-19) had a major impact on the health of people worldwide. The clinical background and clinical course of inflammatory bowel disease (IBD) among Japanese patients with COVID-19 remains unclear. Methods This study is an observational cohort of Japanese IBD patients diagnosed with COVID-19. Data on age, sex, IBD (classification, treatment, and activity), COVID-19 symptoms and severity, and treatment of COVID-19 were analyzed. Results From 72 participating facilities in Japan, 187 patients were registered from June 2020 to October 2021. The estimated incidence of COVID19 in Japanese IBD patients was 0.61%. The majority of IBD patients with COVID-19 (73%) were in clinical remission. According to the WHO classification regarding COVID-19 severity, 93% (172/184) of IBD patients had non-severe episodes, while 7% (12/184) were severe cases including serious conditions. 90.9% (165/187) of IBD patients with COVID-19 had no change in IBD disease activity. A logistic regression analysis stepwise method revealed that older age, higher body mass index (BMI), and steroid use were independent risk factors for COVID-19 severity. Six of nine patients who had COVID-19 after vaccination were receiving anti-tumor necrosis factor (TNF)-α antibodies. Conclusion Age, BMI and steroid use were associated with COVID-19 severity in Japanese IBD patients.