The Journal of infectious diseases, 2022-03, Vol.225 (6), p.977-982
2022
Details
- Autor(en) / Beteiligte
- Titel
- High SARS-CoV-2 Viral Load and Low CCL5 Expression Levels in the Upper Respiratory Tract Are Associated With COVID-19 Severity
- Ist Teil von
- The Journal of infectious diseases, 2022-03, Vol.225 (6), p.977-982
- Ort / Verlag
- US: Oxford University Press
- Erscheinungsjahr
- 2022
- Link zum Volltext
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- Abstract Mucosal immune response in the upper respiratory tract is crucial for initial control of viral replication, clearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and progression of coronavirus disease 2019 (COVID-19). We analyzed SARS-CoV-2 RNA load and expression of selected immune genes in the upper respiratory tract (nasopharynx) of 255 SARS-CoV-2–infected patients and evaluated their association with severe COVID-19. SARS-CoV-2 replication in nasopharyngeal mucosa induces expression of several innate immune genes. High SARS-CoV-2 viral load and low CCL5 expression levels were associated with intensive care unit admission or death, although CCL5 was the best predictor of COVID-19 severity. Graphical Abstract Graphical Abstract
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-1899eISSN: 1537-6613DOI: 10.1093/infdis/jiab604Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8754799
- Format
- –
- Schlagworte
- Body fluids, Chemokine CCL5 - genetics, Chemokine CCL5 - metabolism, Coronaviruses, COVID-19, COVID-19 - diagnosis, COVID-19 - mortality, Humans, Immune clearance, Immune response, Immune system, Intensive Care Units, Major and Brief Reports, Mucosal immunity, Nasopharynx, Nasopharynx - virology, Nose, Pathophysiology, Replication, Respiratory tract, RNA, Viral - genetics, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, Severity of Illness Index, Viral Load