Details

Autor(en) / Beteiligte

• Reid, Shelby
• Scholey, James W

Titel

Recent Approaches to Targeting Canonical NF κ B Signaling in the Early Inflammatory Response to Renal IRI

Ist Teil von

• Journal of the American Society of Nephrology, 2021-09, Vol.32 (9), p.2117-2124

Ort / Verlag

United States: American Society of Nephrology

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Ischemia reperfusion injury (IRI) is the most common cause of in-hospital AKI and is associated with increased morbidity and mortality. IRI is associated with an early phase of inflammation primarily regulated by the canonical NF B signaling pathway. Despite recent advances in our understanding of the pathogenesis of IRI, few therapeutic strategies have emerged. The purpose of this manuscript is to review interventions targeting NF B after IRI.