Details

Autor(en) / Beteiligte

• Arora, Prerna
• Kempf, Amy
• Nehlmeier, Inga
• Graichen, Luise
• Winkler, Martin S.
• Lier, Martin
• Schulz, Sebastian
• Jäck, Hans-Martin
• Pöhlmann, Stefan
• Hoffmann, Markus

Titel

No evidence for increased cell entry or antibody evasion by Delta sublineage AY.4.2

Ist Teil von

• Cellular & molecular immunology, 2022-03, Vol.19 (3), p.449-452

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Since the beginning of the COVID-19 pandemic, multiple SARS-CoV-2 variants have emerged. While some variants spread only locally, others, referred to as variants of concern, disseminated globally and became drivers of the pandemic. All SARS-CoV-2 variants harbor mutations relative to the virus circulating early in the pandemic, and mutations in the viral spike (S) protein are considered of particular relevance since the S protein mediates host cell entry and constitutes the key target of the neutralizing antibody response. As a consequence, mutations in the S protein may increase SARS-CoV-2 infectivity and enable its evasion of neutralizing antibodies. Furthermore, mutations in the S protein can modulate viral transmissibility and pathogenicity.