Details

Autor(en) / Beteiligte

• Mishra, Nibha
• Singh, Malvika
• Singh, Rajendra K
• Saxena, Sandeep

Titel

Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema

Ist Teil von

• Indian journal of ophthalmology, 2021-11, Vol.69 (11), p.3199-3202

Ort / Verlag

India: Wolters Kluwer - Medknow

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Advanced glycation end products (AGEs), due to increased production and a slow turnover rate, serve as mediators of "metabolic memory" even after the resolution of hyperglycemia. A prospective study was undertaken to evaluate the association of AGEs with subfoveal ellipsoid zone (EZ) disruption in diabetic macular edema (DME). A tertiary-care-center-based cross-sectional study included 40 consecutive cases with DME and 20 healthy controls in the age group of 40-65 years. All the study subjects underwent spectral-domain optical coherence tomography (SD-OCT) for cross-sectional imaging of the retina. The EZ was defined as a hyperreflective band below the external limiting membrane. The disruption of EZ was graded as intact EZ and disrupted EZ. Serum AGEs were assessed by assay of N -carboxymethyl-lysine (N -CML) using the standard protocol. Data were analyzed statistically. Subfoveal EZ disruption was noted in 80% (32/40) of the cases of DME. In the cases without EZ disruption, visual acuity (LogMAR VA) was 0.60 ± 0.52, whereas in cases with EZ disruption, LogMAR VA was 0.96 ± 0.56 (P < 0.001). In the cases without EZ disruption, N -CML was 94.31 ± 57 ng/mL, whereas in cases with EZ disruption N -CML was 120.64 ± 71.98 ng/mL (P < 0.001). In DME, increased levels of AGEs are significantly associated with EZ disruption on SD-OCT.