Oxidative medicine and cellular longevity, 2021, Vol.2021, p.3456725-22
2021
Details
- Autor(en) / Beteiligte
- Titel
- Dihydroartemisinin Induces Ferroptosis in HCC by Promoting the Formation of PEBP1/15-LO
- Ist Teil von
- Oxidative medicine and cellular longevity, 2021, Vol.2021, p.3456725-22
- Ort / Verlag
- United States: Hindawi
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Relevant researches have recognized the vital role of inducing ferroptosis in the treatment of tumor. The latest findings indicate that PEBP1/15-LO can play an essential role in the process of cell death. However, its role in regulating ferroptosis in hepatocellular carcinoma (simplified by HCC) remains unclear. The previous research of our team has proved that DHA can induce ferroptosis of hepatic stellate cells. In this study, we found that DHA could also induce ferroptosis in HCC cells. Interestingly, DHA induced ferroptosis by promoting the formation of PEBP1/15-LO and promoting cell membrane lipid peroxidation. In addition, we also found that DHA had no obvious regulatory effect on 15-LO, but it could promote PEBP1 protein expression. Importantly, we discovered the upregulation of PEBP1 induced by DHA was related to the inhibition of its ubiquitination degradation. In vivo experiments have also obtained consistent results that DHA can inhibit tumor growth and affect the expression of ferroptosis markers in tumor tissues, which would be partially offset by interference with PEBP1.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1942-0900eISSN: 1942-0994DOI: 10.1155/2021/3456725Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8683180
- Format
- –
- Schlagworte
- Animals, Antibodies, Antimalarials - pharmacology, Apoptosis, Arachidonate 15-Lipoxygenase - genetics, Arachidonate 15-Lipoxygenase - metabolism, Artemisinins - pharmacology, Biotechnology, Carcinoma, Hepatocellular - drug therapy, Carcinoma, Hepatocellular - metabolism, Carcinoma, Hepatocellular - pathology, Cell cycle, Cell growth, Cell Proliferation, Chinese medicine, Cytotoxicity, Drugs, Fatty acids, Ferroptosis, Gene Expression Regulation, Neoplastic - drug effects, Humans, Lipids, Liver cancer, Liver Neoplasms - drug therapy, Liver Neoplasms - metabolism, Liver Neoplasms - pathology, Male, Mice, Mice, Inbred BALB C, Mice, Nude, Phosphatidylethanolamine Binding Protein - genetics, Phosphatidylethanolamine Binding Protein - metabolism, Proteins, Reagents, Research methodology, Tumor Cells, Cultured, Xenograft Model Antitumor Assays