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Human brain mapping, 2022-01, Vol.43 (1), p.255-277
2022

Details

Autor(en) / Beteiligte
Titel
Mega‐analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group
Ist Teil von
  • Human brain mapping, 2022-01, Vol.43 (1), p.255-277
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2022
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
  • The ENIGMA group on Generalized Anxiety Disorder (ENIGMA‐Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega‐analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between‐country transfer of subject‐level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega‐analyses. This report summarizes the background information and rationale for the various methodological decisions made by the ENIGMA—GAD group. The aim of this work is to help guide other research groups working with large brain imaging data sets.

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