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Increased levels of soluble fms‐like tyrosine kinase‐1 are associated with adverse outcome in pregnant women with COVID‐19
Ultrasound in obstetrics & gynecology, 2022-02, Vol.59 (2), p.202-208
Torres‐Torres, J.
Espino‐y‐Sosa, S.
Poon, L. C.
Solis‐Paredes, J. M.
Estrada‐Gutierrez, G.
Espejel‐Nuñez, A.
Juarez‐Reyes, A.
Etchegaray‐Solana, A.
Alfonso‐Guillen, Y.
Aguilar‐Andrade, L.
Hernández‐Pacheco, J. A.
Villafan‐Bernal, J. R.
Martinez‐Portilla, R. J.
2022
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Torres‐Torres, J.
Espino‐y‐Sosa, S.
Poon, L. C.
Solis‐Paredes, J. M.
Estrada‐Gutierrez, G.
Espejel‐Nuñez, A.
Juarez‐Reyes, A.
Etchegaray‐Solana, A.
Alfonso‐Guillen, Y.
Aguilar‐Andrade, L.
Hernández‐Pacheco, J. A.
Villafan‐Bernal, J. R.
Martinez‐Portilla, R. J.
Titel
Increased levels of soluble fms‐like tyrosine kinase‐1 are associated with adverse outcome in pregnant women with COVID‐19
Ist Teil von
Ultrasound in obstetrics & gynecology, 2022-02, Vol.59 (2), p.202-208
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2022
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
ABSTRACT Objective In addition to the lungs, the placenta and the endothelium can be affected by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and placental growth factor (PlGF) are markers of endothelial dysfunction and could potentially serve as predictors of severe coronavirus disease 2019 (COVID‐19). We aimed to investigate the association of serum concentrations of sFlt‐1 and PlGF with the severity of COVID‐19 in pregnancy. Methods This was a prospective cohort study carried out in a tertiary care hospital in Mexico City, Mexico. Symptomatic pregnant women with a positive reverse‐transcription quantitative polymerase chain reaction test for SARS‐CoV‐2 infection who fulfilled the criteria for hospitalization were included. The primary outcome was severe pneumonia due to COVID‐19. Secondary outcomes were intensive care unit (ICU) admission, viral sepsis and maternal death. sFlt‐1 levels were expressed as multiples of the median (MoM). The association between sFlt‐1 and each adverse outcome was explored by logistic regression analysis, adjusted for gestational age for outcomes occurring in more than five patients, and the predictive performance was assessed by receiver‐operating‐characteristics‐curve analysis. Results Among 113 pregnant women with COVID‐19, higher sFlt‐1 MoM was associated with an increased probability of severe pneumonia (adjusted odds ratio (aOR), 1.817 (95% CI, 1.365–2.418)), ICU admission (aOR, 2.195 (95% CI, 1.582–3.047)), viral sepsis (aOR, 2.318 (95% CI, 1.407–3.820)) and maternal death (unadjusted OR, 5.504 (95% CI, 1.079–28.076)). At a 10% false‐positive rate, sFlt‐1 MoM had detection rates of 45.2%, 66.7%, 83.3% and 100% for severe COVID‐19 pneumonia, ICU admission, viral sepsis and maternal death, respectively. PlGF values were similar between women with severe and those with non‐severe COVID‐19 pneumonia. Conclusion sFlt‐1 MoM is higher in pregnant women with severe COVID‐19 and has the capability to predict serious adverse pregnancy events, such as severe pneumonia, ICU admission, viral sepsis and maternal death. © 2021 International Society of Ultrasound in Obstetrics and Gynecology.
Sprache
Englisch
Identifikatoren
ISSN: 0960-7692
eISSN: 1469-0705
DOI: 10.1002/uog.24798
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8661924
Format
–
Schlagworte
Adult
,
Cohort Studies
,
Coronaviruses
,
COVID-19
,
COVID-19 - blood
,
COVID-19 - diagnosis
,
COVID-19 - epidemiology
,
COVID-19 - therapy
,
Death
,
endothelial dysfunction
,
Endothelium
,
Endothelium, Vascular - metabolism
,
Endothelium, Vascular - physiopathology
,
Female
,
Gestational Age
,
Growth factors
,
Gynecology
,
Humans
,
Intensive Care Units - statistics & numerical data
,
Kinases
,
maternal death
,
Maternal mortality
,
Mexico - epidemiology
,
Mortality
,
Obstetrics
,
Original Paper
,
Original Papers
,
Performance prediction
,
placenta
,
Placenta - metabolism
,
Placenta - physiopathology
,
Placenta Growth Factor - blood
,
placental growth factor
,
Pneumonia
,
Pneumonia, Viral - diagnosis
,
Pneumonia, Viral - epidemiology
,
Pneumonia, Viral - etiology
,
Polymerase chain reaction
,
Pregnancy
,
Pregnancy Complications, Infectious - blood
,
Pregnancy Complications, Infectious - diagnosis
,
Pregnancy Complications, Infectious - epidemiology
,
Pregnancy Complications, Infectious - therapy
,
Protein-tyrosine kinase
,
Regression analysis
,
SARS-CoV-2 - isolation & purification
,
SARS‐CoV‐2
,
Sepsis
,
Severe acute respiratory syndrome
,
Severe acute respiratory syndrome coronavirus 2
,
Severity of Illness Index
,
Statistical analysis
,
Tyrosine
,
Vascular Endothelial Growth Factor Receptor-1 - blood
,
Viral diseases
,
Womens health
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