Details

Autor(en) / Beteiligte

• Martin‐Vicente, María
• Almansa, Raquel
• Martínez, Isidoro
• Tedim, Ana P.
• Bustamante, Elena
• Tamayo, Luis
• Aldecoa, César
• Gómez, José Manuel
• Renedo, Gloria
• Berezo, Jose Ángel
• Cedeño, Jamil Antonio
• Mamolar, Nuria
• García Olivares, Pablo
• Herrán‐Monge, Rubén
• Cicuendez, Ramón
• Enríquez, Pedro
• Ortega, Alicia
• Jorge, Noelia
• Doncel, Cristina
• de la Fuente, Amanda
• Bustamante‐Munguira, Juan
• Muñoz‐Gómez, María José
• González‐Rivera, Milagros
• Puertas, Carolina
• Más, Vicente
• Vázquez, Mónica
• Pérez‐García, Felipe
• Rico‐Feijoo, Jesús
• Martín, Silvia
• Motos, Anna
• Fernandez‐Barat, Laia
• Eiros, Jose María
• Dominguez‐Gil, Marta
• Ferrer, Ricard
• Barbé, Ferrán
• Trapiello, Wysali
• Kelvin, David J.
• Bermejo‐Martin, Jesús F.
• Resino, Salvador
• Torres, Antoni

Titel

Low anti‐SARS‐CoV‐2 S antibody levels predict increased mortality and dissemination of viral components in the blood of critical COVID‐19 patients

Ist Teil von

• Journal of internal medicine, 2022-02, Vol.291 (2), p.232-240

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2022

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Background Anti‐SARS‐CoV‐2 S antibodies prevent viral replication. Critically ill COVID‐19 patients show viral material in plasma, associated with a dysregulated host response. If these antibodies influence survival and viral dissemination in ICU‐COVID patients is unknown. Patients/Methods We studied the impact of anti‐SARS‐CoV‐2 S antibodies levels on survival, viral RNA‐load in plasma, and N‐antigenaemia in 92 COVID‐19 patients over ICU admission. Results Frequency of N‐antigenaemia was >2.5‐fold higher in absence of antibodies. Antibodies correlated inversely with viral RNA‐load in plasma, representing a protective factor against mortality (adjusted HR [CI 95%], p): (S IgM [AUC ≥ 60]: 0.44 [0.22; 0.88], 0.020); (S IgG [AUC ≥ 237]: 0.31 [0.16; 0.61], <0.001). Viral RNA‐load in plasma and N‐antigenaemia predicted increased mortality: (N1‐viral load [≥2.156 copies/ml]: 2.25 [1.16; 4.36], 0.016); (N‐antigenaemia: 2.45 [1.27; 4.69], 0.007). Conclusions Low anti‐SARS‐CoV‐2 S antibody levels predict mortality in critical COVID‐19. Our findings support that these antibodies contribute to prevent systemic dissemination of SARS‐CoV‐2.