Details

Autor(en) / Beteiligte

• Cervantes-Díaz, Rodrigo
• Sosa-Hernández, Víctor Andrés
• Torres-Ruíz, Jiram
• Romero-Ramírez, Sandra
• Cañez-Hernández, Mariana
• Pérez-Fragoso, Alfredo
• Páez-Franco, José C.
• Meza-Sánchez, David E.
• Pescador-Rojas, Miriam
• Sosa-Hernández, Víctor Adrián
• Gómez-Martín, Diana
• Maravillas-Montero, José L.

Titel

Severity of SARS-CoV-2 infection is linked to double-negative (CD27− IgD−) B cell subset numbers

Ist Teil von

• Inflammation research, 2022, Vol.71 (1), p.131-140

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Objectives The role of B cells in COVID‐19, beyond the production of specific antibodies against SARS-CoV-2, is still not well understood. Here, we describe the novel landscape of circulating double-negative (DN) CD27 − IgD − B cells in COVID‐19 patients, representing a group of atypical and neglected subpopulations of this cell lineage. Methods Using multiparametric flow cytometry, we determined DN B cell subset amounts from 91 COVID-19 patients, correlated those with cytokines, clinical and laboratory parameters, and segregated them by principal components analysis. Results We detected significant increments in the DN2 and DN3 B cell subsets, while we found a relevant decrease in the DN1 B cell subpopulation, according to disease severity and patient outcomes. These DN cell numbers also appeared to correlate with pro- or anti-inflammatory signatures, respectively, and contributed to the segregation of the patients into disease severity groups. Conclusion This study provides insights into DN B cell subsets’ potential role in immune responses against SARS‐CoV‐2, particularly linked to the severity of COVID‐19.