Details

Autor(en) / Beteiligte

• Martí-Fàbregas, Joan
• Guisado-Alonso, Daniel
• Delgado-Mederos, Raquel
• Martínez-Domeño, Alejandro
• Prats-Sánchez, Luis
• Guasch-Jiménez, Marina
• Cardona, Pere
• Núñez-Guillén, Ana
• Requena, Manuel
• Rubiera, Marta
• Olivé, Marta
• Bustamante, Alejandro
• Gomis, Meritxell
• Amaro, Sergio
• Llull, Laura
• Ustrell, Xavier
• Castilho de Oliveira, Gislaine
• Seró, Laia
• Gomez-Choco, Manuel
• Mena, Luis
• Serena, Joaquín
• Bashir Viturro, Saima
• Purroy, Francisco
• Vicente, Mikel
• Rodríguez-Campello, Ana
• Ois, Angel
• Catena, Esther
• Carmen Garcia-Carreira, Maria
• Barrachina, Oriol
• Palomeras, Ernest
• Krupinski, Jerzky
• Almeria, Marta
• Zaragoza, Josep
• Esteve, Patricia
• Cocho, Dolores
• Moreira, Antia
• van Eendenburg, Cecile
• Emilio Codas, Javier
• Pérez de la Ossa, Natalia
• Salvat, Mercè
• Camps-Renom, Pol

Titel

Impact of COVID-19 Infection on the Outcome of Patients With Ischemic Stroke

Ist Teil von

• Stroke (1970), 2021-12, Vol.52 (12), p.3908-3917

Ort / Verlag

United States: Lippincott Williams & Wilkins

Erscheinungsjahr

2021

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• We evaluated whether stroke severity, functional outcome, and mortality are different in patients with ischemic stroke with or without coronavirus disease 2019 (COVID-19) infection. A prospective, observational, multicentre cohort study in Catalonia, Spain. Recruitment was consecutive from mid-March to mid-May 2020. Patients had an acute ischemic stroke within 48 hours and a previous modified Rankin Scale (mRS) score of 0 to 3. We collected demographic data, vascular risk factors, prior mRS score, National Institutes of Health Stroke Scale score, rate of reperfusion therapies, logistics, and metrics. Primary end point was functional outcome at 3 months. Favourable outcome was defined depending on the previous mRS score. Secondary outcome was mortality at 3 months. We performed mRS shift and multivariable analyses. We evaluated 701 patients (mean age 72.3±13.3 years, 60.5% men) and 91 (13%) had COVID-19 infection. Median baseline National Institutes of Health Stroke Scale score was higher in patients with COVID-19 compared with patients without COVID-19 (8 [3-18] versus 6 [2-14], =0.049). Proportion of patients with a favourable functional outcome was 33.7% in the COVID-19 and 47% in the non-COVID-19 group. However, after a multivariable logistic regression analysis, COVID-19 infection did not increase the probability of unfavourable functional outcome. Mortality rate was 39.3% among patients with COVID-19 and 16.1% in the non-COVID-19 group. In the multivariable logistic regression analysis, COVID-19 infection was a risk factor for mortality (hazard ratio, 3.14 [95% CI, 2.10-4.71]; <0.001). Patients with ischemic stroke and COVID-19 infection have more severe strokes and a higher mortality than patients with stroke without COVID-19 infection. However, functional outcome is comparable in both groups.